Literature DB >> 21667154

A simple integrative electrophysiological model of bursting GnRH neurons.

Dávid Csercsik1, Imre Farkas, Erik Hrabovszky, Zsolt Liposits.   

Abstract

In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics are described by usual ordinary differential equations (ODEs). The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21667154     DOI： 10.1007/s10827-011-0343-y

Source DB:  PubMed          Journal:  J Comput Neurosci        ISSN： 0929-5313            Impact factor:   1.621


  63 in total

1.  Spontaneous action potentials initiate rhythmic intercellular calcium waves in immortalized hypothalamic (GT1-1) neurons.

Authors:  J L Costantin; A C Charles
Journal:  J Neurophysiol       Date:  1999-07       Impact factor: 2.714

2.  Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology.

Authors:  K J Suter; W J Song; T L Sampson; J P Wuarin; J T Saunders; F E Dudek; S M Moenter
Journal:  Endocrinology       Date:  2000-01       Impact factor: 4.736

3.  High expression of the R-type voltage-gated Ca2+ channel and its involvement in Ca2+-dependent gonadotropin-releasing hormone release in GT1-7 cells.

Authors:  Miho Watanabe; Yasuo Sakuma; Masakatsu Kato
Journal:  Endocrinology       Date:  2004-01-21       Impact factor: 4.736

4.  Spike-dependent depolarizing afterpotentials contribute to endogenous bursting in gonadotropin releasing hormone neurons.

Authors:  M C Kuehl-Kovarik; K M Partin; R J Handa; F E Dudek
Journal:  Neuroscience       Date:  2005       Impact factor: 3.590

Review 5.  Neurokinin B and the hypothalamic regulation of reproduction.

Authors:  Naomi E Rance; Sally J Krajewski; Melinda A Smith; Marina Cholanian; Penny A Dacks
Journal:  Brain Res       Date:  2010-08-25       Impact factor: 3.252

6.  A mathematical model of adult GnRH neurons in mouse brain and its bifurcation analysis.

Authors:  Wen Duan; Kiho Lee; Allan E Herbison; James Sneyd
Journal:  J Theor Biol       Date:  2011-02-25       Impact factor: 2.691

7.  Differential regulation of gonadotropin-releasing hormone neuron activity and membrane properties by acutely applied estradiol: dependence on dose and estrogen receptor subtype.

Authors:  Zhiguo Chu; Josefa Andrade; Margaret A Shupnik; Suzanne M Moenter
Journal:  J Neurosci       Date:  2009-04-29       Impact factor: 6.167

8.  Endogenous GABA release inhibits the firing of adult gonadotropin-releasing hormone neurons.

Authors:  Seong-Kyu Han; Martin G Todman; Allan E Herbison
Journal:  Endocrinology       Date:  2003-11-14       Impact factor: 4.736

9.  Synaptic integration in hypothalamic gonadotropin releasing hormone (GnRH) neurons.

Authors:  C B Roberts; P Hemond; K J Suter
Journal:  Neuroscience       Date:  2008-05-09       Impact factor: 3.590

Review 10.  Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent: the case for the rostral periventricular area of the third ventricle (RP3V).

Authors:  Allan E Herbison
Journal:  Brain Res Rev       Date:  2007-06-02
View more
  2 in total

1.  Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Bötzinger complex neurons.

Authors:  Choongseok Park; Jonathan E Rubin
Journal:  J Comput Neurosci       Date:  2012-09-28       Impact factor: 1.621

2.  A unified model for two modes of bursting in GnRH neurons.

Authors:  Spencer Moran; Suzanne M Moenter; Anmar Khadra
Journal:  J Comput Neurosci       Date:  2016-03-15       Impact factor: 1.621
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.