| Literature DB >> 21667036 |
Chunsun Li1, Liwei Chen, Jialing Wang, Liyong Zhang, Pingzhang Tang, Suoqiang Zhai, Weiwei Guo, Ning Yu, Lidong Zhao, Mingbo Liu, Shiming Yang.
Abstract
The aim of this study was to investigate the roles of the cathepsin B cysteine protease and its endogenous inhibitor stefin A in laryngeal cancer. Immunohistochemistry was employed to detect the expression of cathepsin B and stefin A in 84 patients with laryngeal cancer, respectively. The protein expression of stefin A was negatively associated with lymphatic metastasis, recurrence of laryngeal cancer and the survival rate, which was not observed with cathepsin B protein expression. Both down-regulation of cathepsin B and up-regulation of stefin A in vitro significantly inhibited the migration, invasion and proliferation of laryngeal cancer cells, respectively. Our results strongly suggest that stefin A may be a potential predictor of laryngeal cancer and may be used in the molecular diagnosis and gene therapy of laryngeal cancer. Cathepsin B may be used as a promising therapeutic target in the treatment of laryngeal cancer.Entities:
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Year: 2011 PMID： 21667036 DOI： 10.3892/or.2011.1344
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906