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Literature DB >> 21665869

Alcohol attenuates activation in the bilateral anterior insula during an emotional processing task: a pilot study.

Claudia B Padula¹, Alan N Simmons, Scott C Matthews, Shannon K Robinson, Susan F Tapert, Marc A Schuckit, Martin P Paulus.

Abstract

AIMS: Alcohol acutely reduces agitation and is widely used in social situations, but the neural substrates of emotion processing during its intoxication are not well understood. We examine whether alcohol's social stress dampening effect may be via reduced activity in the cortical systems that subserve awareness of bodily sensations, and are associated with affective distress.
METHODS: Blood oxygen level-dependent activation was measured through 24 functional magnetic resonance imaging sessions in 12 healthy volunteers during an emotional face-processing task following ingestion of a moderate dose of alcohol and a placebo beverage.
RESULTS: Results revealed that bilateral anterior insula response to emotional faces was significantly attenuated following consumption of alcohol, when compared with placebo (clusters >1472 μl; corrected P < 0.05).
CONCLUSION: Attenuated response in the anterior insula after alcohol intake may explain some of the decreased interoceptive awareness described during intoxication.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2011 PMID： 21665869 PMCID： PMC3201697 DOI： 10.1093/alcalc/agr066

Source DB: PubMed Journal: Alcohol Alcohol ISSN： 0735-0414 Impact factor: 2.826

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7. Increased amygdala and insula activation during emotion processing in anxiety-prone subjects.

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8. Dissociating pain from its anticipation in the human brain.

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9. Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing.

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17 in total

Alcohol attenuates activation in the bilateral anterior insula during an emotional processing task: a pilot study.

1. Functional neuroanatomy of aversion and its anticipation.

2. Predictability modulates the affective and sensory-discriminative neural processing of pain.

3. Expecting unpleasant stimuli--an fMRI study.

4. Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects.

5. Damage to the insula disrupts addiction to cigarette smoking.

6. Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol.

7. Increased amygdala and insula activation during emotion processing in anxiety-prone subjects.

8. Dissociating pain from its anticipation in the human brain.

9. Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing.

10. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.

1. Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons.

2. Unbalanced neuronal circuits in addiction.

3. Resting-state synchrony during early alcohol abstinence can predict subsequent relapse.

4. Gender effects in alcohol dependence: an fMRI pilot study examining affective processing.

5. Evaluation of Interoceptive Awareness in Alcohol-Addicted Patients.

Review 6. The effects of acute alcohol administration on the human brain: insights from neuroimaging.

7. Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users.

8. Acute effects of alcohol on resting-state functional connectivity in healthy young men.

Review 9. Alcohol use and interoception - A narrative review.

10. A Distinct Neurophenotype of Fearful Face Processing in Alcohol Use Disorder With and Without Comorbid Anxiety.