| Literature DB >> 21665453 |
L R Comini1, I M Fernandez, N B Rumie Vittar, S C Núñez Montoya, J L Cabrera, V A Rivarola.
Abstract
Searching for agents that could be effective in the treatment of cancer, special highlight has focused on the study of numerous plant-derived compounds. We previously demonstrated that anthraquinones (AQs) isolated from a vegetal species: Heterophyllaea pustulata Hook f. (Rubiaceae), such as rubiadin, rubiadin-1-methyl ether, soranjidiol, soranjidiol-1-methyl ether exhibit photosensitizing properties without antecedents as photodynamic agents in malignant cells. In the present study, we investigated the potential role of these AQs as a phototoxic agent against human breast carcinoma using MCF-7c3 cells. All AQs exhibited significant photocytotoxicity on cancer cells at the concentration of 100 μM with 1 J/cm(2) light dose, resulting soranjidiol-1-methyl ether in complete cell destruction. The observed cellular killing by photoactivated AQs exhibited close relation with singlet oxygen production, except for soranjidiol-1-methyl ether, where cell viability decrease is in relation to uptake by tumor cells.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21665453 DOI： 10.1016/j.phymed.2011.05.008
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340