Literature DB >> 21665143

ROCK-driven actomyosin contractility induces tissue stiffness and tumor growth.

Sandra Kümper1, Christopher J Marshall.   

Abstract

The tumor environment consists of tumor-associated cells, such as macrophages, fibroblasts, and extracellular matrix, and has an important impact on tumor progression. In this issue of Cancer Cell, Samuel et al. show that ROCK-driven actomyosin contractility increases tissue stiffness affecting epidermal homeostasis, as well as tumor growth and progression.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21665143     DOI： 10.1016/j.ccr.2011.05.021

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  12 in total

1.  Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.

Authors:  Sophie Y Wong; Theresa A Ulrich; Loic P Deleyrolle; Joanna L MacKay; Jung-Ming G Lin; Regina T Martuscello; Musa A Jundi; Brent A Reynolds; Sanjay Kumar
Journal:  Cancer Res       Date:  2015-01-29       Impact factor: 12.701

2.  Senescent mesenchymal stem cells remodel extracellular matrix driving breast cancer cells to a more-invasive phenotype.

Authors:  Deepraj Ghosh; Carolina Mejia Pena; Nhat Quach; Botai Xuan; Amy H Lee; Michelle R Dawson
Journal:  J Cell Sci       Date:  2020-01-23       Impact factor: 5.285

3.  Rho kinase inhibition maintains intestinal and vascular barrier function by upregulation of occludin in experimental necrotizing enterocolitis.

Authors:  Justyna S Grothaus; Guillermo Ares; Carrie Yuan; Douglas R Wood; Catherine J Hunter
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-06-21       Impact factor: 4.052

4.  Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.

Authors:  Junbo Zhang; Xue He; Yueying Ma; Yanli Liu; Huaiyin Shi; Weiwei Guo; Liangfa Liu
Journal:  Int J Clin Exp Pathol       Date:  2015-01-01

5.  Integrin αvβ3 and fibronectin upregulate Slug in cancer cells to promote clot invasion and metastasis.

Authors:  Lynn M Knowles; Lisa A Gurski; Charlotte Engel; James R Gnarra; Jodi K Maranchie; Jan Pilch
Journal:  Cancer Res       Date:  2013-08-21       Impact factor: 12.701

6.  Human subperitoneal fibroblast and cancer cell interaction creates microenvironment that enhances tumor progression and metastasis.

Authors:  Motohiro Kojima; Youichi Higuchi; Mitsuru Yokota; Genichiro Ishii; Norio Saito; Kazuhiko Aoyagi; Hiroki Sasaki; Atsushi Ochiai
Journal:  PLoS One       Date:  2014-02-04       Impact factor: 3.240

7.  Ovarian Cancer Exosomes Trigger Differential Biophysical Response in Tumor-Derived Fibroblasts.

Authors:  Amy H Lee; Deepraj Ghosh; Nhat Quach; Devin Schroeder; Michelle R Dawson
Journal:  Sci Rep       Date:  2020-05-26       Impact factor: 4.379

8.  Cytoskeletal alteration modulates cancer cell invasion through RhoA-YAP signaling in stromal fibroblasts.

Authors:  Do Kyeong Kim; Eun Kyoung Kim; Da-Woon Jung; Jin Kim
Journal:  PLoS One       Date:  2019-03-28       Impact factor: 3.240

9.  Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.

Authors:  Hong Jiang; Samarth Hegde; Brett L Knolhoff; Yu Zhu; John M Herndon; Melissa A Meyer; Timothy M Nywening; William G Hawkins; Irina M Shapiro; David T Weaver; Jonathan A Pachter; Andrea Wang-Gillam; David G DeNardo
Journal:  Nat Med       Date:  2016-07-04       Impact factor: 53.440

10.  Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

Authors:  Hyun-Taek Kim; Wenguang Yin; Young-June Jin; Paolo Panza; Felix Gunawan; Beate Grohmann; Carmen Buettner; Anna M Sokol; Jens Preussner; Stefan Guenther; Sawa Kostin; Clemens Ruppert; Aditya M Bhagwat; Xuefei Ma; Johannes Graumann; Mario Looso; Andreas Guenther; Robert S Adelstein; Stefan Offermanns; Didier Y R Stainier
Journal:  Nat Commun       Date:  2018-11-02       Impact factor: 14.919
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.