BACKGROUND:Tai Chi Chuan (TCC) is an integrative medicine mind-body practice with a physical activity component that has positive effects on aerobic capacity, muscular strength, and quality of life among cancer survivors, similar to the effects elicited by other modes of moderate-intensity exercise. Inflammatory cytokines and insulin and insulin-related signaling molecules may contribute to weight gain and affect cancer recurrence rates and survival; exercise can curb cancer- and treatment-related weight gain, increase survival, and reduce levels of insulin and inflammatory cytokines. Despite knowing the beneficial effects of conventional exercise interventions on these mediators, little is known about the physiologic effects of TCC on these pathways in breast cancer survivors. METHODS: We assessed the effects of a 12-week, moderately intense, TCC intervention (n = 9) compared with a non-physical activity control (n = 10) consisting of psychosocial support therapy (PST), on levels of insulin, insulin-like growth factor (IGF)-1, insulin growth factor-like binding protein (IGFBP)-1, IGFBP-3, and cytokines interleukin (IL)-6, IL-2, and interferon (IFN)-γ in breast cancer survivors. RESULTS:Levels of insulin are significantly different in TCC and PST groups; levels remained stable in the TCC group but increased in the PST control group (P = .099). Bivariate analysis revealed novel and significant correlations (all r > 0.45, all P ≤ .05) of both decreased fat mass and increased fat-free mass with increased IL-6 and decreased IL-2 levels. CONCLUSIONS: This pilot study shows that TCC may be associated with maintenance of insulin levels and changes in cytokine levels that may be important for maintenance of lean body mass in breast cancer survivors.
RCT Entities:
BACKGROUND: Tai Chi Chuan (TCC) is an integrative medicine mind-body practice with a physical activity component that has positive effects on aerobic capacity, muscular strength, and quality of life among cancer survivors, similar to the effects elicited by other modes of moderate-intensity exercise. Inflammatory cytokines and insulin and insulin-related signaling molecules may contribute to weight gain and affect cancer recurrence rates and survival; exercise can curb cancer- and treatment-related weight gain, increase survival, and reduce levels of insulin and inflammatory cytokines. Despite knowing the beneficial effects of conventional exercise interventions on these mediators, little is known about the physiologic effects of TCC on these pathways in breast cancer survivors. METHODS: We assessed the effects of a 12-week, moderately intense, TCC intervention (n = 9) compared with a non-physical activity control (n = 10) consisting of psychosocial support therapy (PST), on levels of insulin, insulin-like growth factor (IGF)-1, insulin growth factor-like binding protein (IGFBP)-1, IGFBP-3, and cytokines interleukin (IL)-6, IL-2, and interferon (IFN)-γ in breast cancer survivors. RESULTS: Levels of insulin are significantly different in TCC and PST groups; levels remained stable in the TCC group but increased in the PST control group (P = .099). Bivariate analysis revealed novel and significant correlations (all r > 0.45, all P ≤ .05) of both decreased fat mass and increased fat-free mass with increased IL-6 and decreased IL-2 levels. CONCLUSIONS: This pilot study shows that TCC may be associated with maintenance of insulin levels and changes in cytokine levels that may be important for maintenance of lean body mass in breast cancer survivors.
Authors: Jennifer S Yates; Karen M Mustian; Gary R Morrow; Leslie J Gillies; Devi Padmanaban; James N Atkins; Brian Issell; Jeffrey J Kirshner; Lauren K Colman Journal: Support Care Cancer Date: 2005-02-15 Impact factor: 3.603
Authors: Melinda L Irwin; Anne McTiernan; Leslie Bernstein; Frank D Gilliland; Richard Baumgartner; Kathy Baumgartner; Rachel Ballard-Barbash Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-12 Impact factor: 4.254
Authors: Patrick Mansky; Tim Sannes; Dawn Wallerstedt; Adeline Ge; Mary Ryan; Laura Lee Johnson; Margaret Chesney; Lynn Gerber Journal: Integr Cancer Ther Date: 2006-09 Impact factor: 3.279
Authors: Page E Abrahamson; Marilie D Gammon; Mary Jo Lund; Julie A Britton; Stephen W Marshall; Elaine W Flagg; Peggy L Porter; Louise A Brinton; J William Eley; Ralph J Coates Journal: Cancer Date: 2006-10-15 Impact factor: 6.860
Authors: Bette J Caan; Jennifer A Emond; Loki Natarajan; Adrienne Castillo; Erica P Gunderson; Laurel Habel; Lovell Jones; Vicky A Newman; Cheryl L Rock; Martha L Slattery; Marcia L Stefanick; Barbara Sternfeld; Cynthia A Thomson; John P Pierce Journal: Breast Cancer Res Treat Date: 2006-03-16 Impact factor: 4.872
Authors: Laura K Stewart; Michael G Flynn; Wayne W Campbell; Bruce A Craig; J Paul Robinson; Kyle L Timmerman; Brian K McFarlin; Paul M Coen; Erin Talbert Journal: Med Sci Sports Exerc Date: 2007-10 Impact factor: 5.411
Authors: Lisa K Sprod; Michelle C Janelsins; Oxana G Palesh; Jennifer K Carroll; Charles E Heckler; Luke J Peppone; Supriya G Mohile; Gary R Morrow; Karen M Mustian Journal: J Cancer Surviv Date: 2011-12-10 Impact factor: 4.442
Authors: Xiaosha Ni; Raymond Javan Chan; Patsy Yates; Wenyi Hu; Xianhong Huang; Yan Lou Journal: Support Care Cancer Date: 2019-06-24 Impact factor: 3.603
Authors: Karen M Mustian; Calvin L Cole; Po Ju Lin; Matt Asare; Chunkit Fung; Michelle C Janelsins; Charles S Kamen; Luke J Peppone; Allison Magnuson Journal: Semin Oncol Nurs Date: 2016-10-21 Impact factor: 2.315
Authors: Linda K Larkey; Denise J Roe; Karen L Weihs; Roger Jahnke; Ana Maria Lopez; Carol E Rogers; Byeongsang Oh; Jose Guillen-Rodriguez Journal: Ann Behav Med Date: 2015-04
Authors: S Casla; P Hojman; I Márquez-Rodas; S López-Tarruella; Y Jerez; R Barakat; M Martín Journal: Clin Transl Oncol Date: 2014-06-04 Impact factor: 3.405