Literature DB >> 21664909

PANcreatic-DERived factor: novel hormone PANDERing to glucose regulation.

Camella G Wilson1, Claudia E Robert-Cooperman, Brant R Burkhardt.   

Abstract

PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-cells. Initial characterization of PANDER revealed a potential role in pancreatic islet apoptosis. However, recent animal models have indicated PANDER functions as a hormone by regulating glucose levels via interaction with both the liver and the endocrine pancreas. An understanding of the function of PANDER can further the insight into the mechanisms of glucose regulation and potentially provide additional therapeutic targets for the treatment of diabetes. This review details the supporting data demonstrating PANDER has a biological function in glycemic regulation.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21664909      PMCID： PMC5789785          DOI： 10.1016/j.febslet.2011.05.059

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  39 in total

1.  Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans.

Authors:  E Hartter; T Svoboda; B Ludvik; M Schuller; B Lell; E Kuenburg; M Brunnbauer; W Woloszczuk; R Prager
Journal:  Diabetologia       Date:  1991-01       Impact factor: 10.122

2.  Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets.

Authors:  R Gasa; R Gomis; R Casamitjana; F Rivera; A Novials
Journal:  Am J Physiol       Date:  1997-04

3.  Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway.

Authors:  Jing Li; Yujing Chi; Chunjiong Wang; Jing Wu; Hang Yang; Dongjuan Zhang; Yi Zhu; Nanping Wang; Jichun Yang; Youfei Guan
Journal:  Hepatology       Date:  2011-05-02       Impact factor: 17.425

4.  Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.

Authors:  Peer B Jacobson; Thomas W von Geldern; Lars Ohman; Marie Osterland; Jiahong Wang; Bradley Zinker; Denise Wilcox; Phong T Nguyen; Amanda Mika; Steven Fung; Thomas Fey; Annika Goos-Nilsson; Marlena Grynfarb; Tomas Barkhem; Kennan Marsh; David W A Beno; Bach Nga-Nguyen; Philip R Kym; James T Link; Noah Tu; Dale S Edgerton; Alan Cherrington; Suad Efendic; Benjamin C Lane; Terry J Opgenorth
Journal:  J Pharmacol Exp Ther       Date:  2005-03-22       Impact factor: 4.030

5.  Differential changes in islet amyloid polypeptide (amylin) and insulin mRNA expression after high-fat diet-induced insulin resistance in C57BL/6J mice.

Authors:  H Mulder; H Mårtensson; F Sundler; B Ahrén
Journal:  Metabolism       Date:  2000-12       Impact factor: 8.694

6.  Inhibition of ADRP prevents diet-induced insulin resistance.

Authors:  Gladys M Varela; Daniel A Antwi; Ravindra Dhir; Xiaoyan Yin; Neel S Singhal; Mark J Graham; Roseanne M Crooke; Rexford S Ahima
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-07-31       Impact factor: 4.052

7.  Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function.

Authors:  Claudia E Robert-Cooperman; Jason R Carnegie; Camella G Wilson; Jichun Yang; Joshua R Cook; Jianmei Wu; Robert A Young; Bryan A Wolf; Brant R Burkhardt
Journal:  Diabetes       Date:  2010-06-21       Impact factor: 9.461

8.  PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter.

Authors:  Brant R Burkhardt; Joshua R Cook; Robert A Young; Bryan A Wolf
Journal:  Biochim Biophys Acta       Date:  2008-07-29

9.  Decrease of stimulated amylin release precedes impairment of insulin secretion in type II diabetes.

Authors:  B Ludvik; B Lell; E Hartter; C Schnack; R Prager
Journal:  Diabetes       Date:  1991-12       Impact factor: 9.461

10.  Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.

Authors:  R A DeFronzo; E Ferrannini; D C Simonson
Journal:  Metabolism       Date:  1989-04       Impact factor: 8.694
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  10 in total

1.  Quantitative proteomic profiling reveals hepatic lipogenesis and liver X receptor activation in the PANDER transgenic model.

Authors:  Mark G Athanason; Whitney A Ratliff; Dale Chaput; Catherine B MarElia; Melanie N Kuehl; Stanley M Stevens; Brant R Burkhardt
Journal:  Mol Cell Endocrinol       Date:  2016-07-07       Impact factor: 4.102

2.  Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan.

Authors:  Naoyuki Kuwabara; Hiroshi Manya; Takeyuki Yamada; Hiroaki Tateno; Motoi Kanagawa; Kazuhiro Kobayashi; Keiko Akasaka-Manya; Yuriko Hirose; Mamoru Mizuno; Mitsunori Ikeguchi; Tatsushi Toda; Jun Hirabayashi; Toshiya Senda; Tamao Endo; Ryuichi Kato
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-04       Impact factor: 11.205

3.  The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus.

Authors:  Fangfang Zhang; Xuechen Zhu; Pan Wang; Qing He; Huimei Huang; Tianrui Zheng; Yongyu Li; Hong Jia; Linping Xu; Huaxiang Zhao; Gabriele Colozza; Qinghua Tao; Edward M De Robertis; Yi Ding
Journal:  Proc Natl Acad Sci U S A       Date:  2021-05-18       Impact factor: 11.205

4.  FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-XL cell survival genes.

Authors:  Paula Maciel-Silva; Izabela Caldeira; Icaro de Assis Santos; Ana Claudia Oliveira Carreira; Flavia Ramos Siqueira; Eliane Antonioli; Anna Carla Goldberg; José Ernesto Belizário; Humberto Miguel Garay-Malpartida
Journal:  BMC Cancer       Date:  2018-01-22       Impact factor: 4.430

5.  FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of miR-322-5p.

Authors:  Wenxiang Zhang; Siyu Chen; Zhao Zhang; Chen Wang; Chang Liu
Journal:  Sci Rep       Date:  2017-05-23       Impact factor: 4.379

6.  Circulating PANDER concentration is associated with increased HbA1c and fasting blood glucose in Type 2 diabetic subjects.

Authors:  Catherine B MarElia; Melanie N Kuehl; Tiffany A Shemwell; Amy C Alman; Brant R Burkhardt
Journal:  J Clin Transl Endocrinol       Date:  2018-02-23

7.  Effects of circulating member B of the family with sequence similarity 3 on the risk of developing metabolic syndrome and its components: A 5-year prospective study.

Authors:  Haoyu Wang; Fadong Yu; Zhuo Zhang; Yuanyuan Hou; Weiping Teng; Zhongyan Shan; Yaxin Lai
Journal:  J Diabetes Investig       Date:  2018-01-03       Impact factor: 4.232

8.  Identifying potential therapeutic targets of Tang-Yi-Ping for the treatment of impaired glucose tolerance: a tandem mass tag-labeled quantitative proteomic analysis.

Authors:  Jie Li; Shuai Bu; Honglei Zhou; Siling Bi; Yunsheng Xu
Journal:  Ann Transl Med       Date:  2021-10

9.  Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice.

Authors:  Shari L Moak; Grace C Dougan; Catherine B MarElia; Whitney A Danse; Amanda M Fernandez; Melanie N Kuehl; Mark G Athanason; Brant R Burkhardt
Journal:  Dis Model Mech       Date:  2014-09-12       Impact factor: 5.758

10.  Elevated circulating level of a cytokine, pancreatic-derived factor, is associated with metabolic syndrome components in a Chinese population.

Authors:  Xiaopei Cao; Chijiao Yang; Fenghua Lai; Zhenzhen Hong; Huimei Lin; Juan Liu; Yanbing Li
Journal:  J Diabetes Investig       Date:  2015-11-14       Impact factor: 4.232
  10 in total

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