Literature DB >> 2166488

Effects of interferon gamma on cultured synovial cells from patients with rheumatoid arthritis: inhibition of cell growth, prostaglandin E2, and collagenase release.

H Nakajima1, Y Hiyama, W Tsukada, H Warabi, S Uchida, S Hirose.   

Abstract

The effects of recombinant interferon gamma (rIFN gamma) on the in vitro growth of adherent synovial fibroblast-like cells from patients with rheumatoid arthritis (RA) and also on the release of prostaglandin E2 and collagenase from these cells stimulated with recombinant interleukin-1 beta (rIL-1 beta) were investigated. The growth of adherent synovial cells from six of nine samples, determined by [3H]thymidine incorporation, was inhibited by rIFN gamma in a manner dependent on dose. The release of prostaglandin E2 and collagenase from adherent synovial cells stimulated with rIL-1 beta was also suppressed by rIFN gamma in all samples tested, though the basal release of these inflammatory mediators was little influenced. No apparent correlation between inhibition of proliferation by rIFN gamma and either inhibition by rIFN gamma of rIL-1 beta stimulated prostaglandin E2 release or the endogenous synthesis of prostaglandins was found.

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Year:  1990        PMID： 2166488      PMCID： PMC1004139          DOI： 10.1136/ard.49.7.512

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  37 in total

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Authors:  R M Friedman; S N Vogel
Journal:  Adv Immunol       Date:  1983       Impact factor: 3.543

Review 2.  Interferons: biochemical, cell growth inhibitory, and immunological effects.

Authors:  E C Borden; L A Ball
Journal:  Prog Hematol       Date:  1981

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Authors:  J Rosenbloom; G Feldman; B Freundlich; S A Jimenez
Journal:  Biochem Biophys Res Commun       Date:  1984-08-30       Impact factor: 3.575

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Authors:  J A Schmidt; S B Mizel; D Cohen; I Green
Journal:  J Immunol       Date:  1982-05       Impact factor: 5.422

5.  Isolation of an interleukin-1-like factor from human joint effusions.

Authors:  D D Wood; E J Ihrie; C A Dinarello; P L Cohen
Journal:  Arthritis Rheum       Date:  1983-08

6.  Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

Authors:  J M Dayer; S M Krane; R G Russell; D R Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

7.  Immune interferon in serum and synovial fluid in rheumatoid arthritis and related disorders.

Authors:  M DeGré; O J Mellbye; O Clarke-Jenssen
Journal:  Ann Rheum Dis       Date:  1983-12       Impact factor: 19.103

8.  Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production.

Authors:  D Boraschi; S Censini; A Tagliabue
Journal:  J Immunol       Date:  1984-08       Impact factor: 5.422

9.  Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation.

Authors:  M R Duncan; B Berman
Journal:  J Exp Med       Date:  1985-08-01       Impact factor: 14.307

10.  Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation.

Authors:  F Hasler; H G Bluestein; N J Zvaifler; L B Epstein
Journal:  J Exp Med       Date:  1983-01-01       Impact factor: 14.307
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  6 in total

1.  Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1.

Authors:  Hao H Ho; Taras T Antoniv; Jong-Dae Ji; Lionel B Ivashkiv
Journal:  J Immunol       Date:  2008-10-01       Impact factor: 5.422

2.  Differential inhibitory effects of indomethacin, dexamethasone, and interferon-gamma (IFN-gamma) on IL-11 production by rheumatoid synovial cells.

Authors:  H Taki; E Sugiyama; T Mino; A Kuroda; M Kobayashi
Journal:  Clin Exp Immunol       Date:  1998-04       Impact factor: 4.330

3.  IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma.

Authors:  L L Reznikov; S H Kim; J Y Westcott; J Frishman; G Fantuzzi; D Novick; M Rubinstein; C A Dinarello
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

4.  Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis.

Authors:  J L Funk; L A Cordaro; H Wei; J B Benjamin; D E Yocum
Journal:  J Clin Invest       Date:  1998-04-01       Impact factor: 14.808

5.  Differential expression of gelatinase B (MMP-9) and stromelysin-1 (MMP-3) by rheumatoid synovial cells in vitro and in vivo.

Authors:  L C Tetlow; M Lees; Y Ogata; H Nagase; D E Woolley
Journal:  Rheumatol Int       Date:  1993       Impact factor: 2.631

6.  Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis.

Authors:  Brian J Schmidt; Fergal P Casey; Thomas Paterson; Jason R Chan
Journal:  BMC Bioinformatics       Date:  2013-07-10       Impact factor: 3.169
  6 in total

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