| Literature DB >> 21664730 |
Bapurao B Shingate1, Braja G Hazra, Deepak B Salunke, Vandana S Pore, Fazal Shirazi, Mukund V Deshpande.
Abstract
Stereoselective synthesis of novel steroidal C-20 tertiary alcohols with thiazole and pyridine side chain using Grignard reaction of steroidal ketones and thiazole/pyridine magnesium bromide have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains.Entities:
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Year: 2011 PMID： 21664730 DOI： 10.1016/j.ejmech.2011.05.032
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514