| Literature DB >> 21664113 |
Fan Xu1, Daiyin Peng, Chunlei Tao, Dengke Yin, Junping Kou, Danni Zhu, Boyang Yu.
Abstract
Anti-depression effects of Danggui-Shaoyao-San (DSS, 1.8-7.2g/kg, orally), a famous Chinese compound prescription with a fixed combination, on forced swimming test (FST) and chronic unpredictable mild stress (CUMS) model were investigated. DSS (7.2g/kg, orally, 7 days) shortened immobility time in FST model and DSS (3.6 or 7.2g/kg, orally, 21 days) increased the open-field activities and the percentage of sugar preference in CUMS model. DSS (7.2g/kg, orally, 21 days) also decreased the content of arginine vasopressin (AVP) in the pituitary and the expression of AVP mRNA in hypothalamus compared with the stress control group. These results demonstrated for the first time DSS has anti-depression effect and it may be influencing the central AVP system.Entities:
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Year: 2011 PMID： 21664113 DOI： 10.1016/j.phymed.2011.05.002
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340