Literature DB >> 21663789

The human brain in a dish: the promise of iPSC-derived neurons.

Ricardo Dolmetsch1, Daniel H Geschwind.   

Abstract

Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21663789      PMCID： PMC3691069          DOI： 10.1016/j.cell.2011.05.034

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  20 in total

1.  A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.

Authors:  Maria C N Marchetto; Cassiano Carromeu; Allan Acab; Diana Yu; Gene W Yeo; Yangling Mu; Gong Chen; Fred H Gage; Alysson R Muotri
Journal:  Cell       Date:  2010-11-12       Impact factor: 41.582

2.  Modelling schizophrenia using human induced pluripotent stem cells.

Authors:  Kristen J Brennand; Anthony Simone; Jessica Jou; Chelsea Gelboin-Burkhart; Ngoc Tran; Sarah Sangar; Yan Li; Yangling Mu; Gong Chen; Diana Yu; Shane McCarthy; Jonathan Sebat; Fred H Gage
Journal:  Nature       Date:  2011-04-13       Impact factor: 49.962

3.  Penetrance for copy number variants associated with schizophrenia.

Authors:  Evangelos Vassos; David A Collier; Simon Holden; Christine Patch; Dan Rujescu; David St Clair; Cathryn M Lewis
Journal:  Hum Mol Genet       Date:  2010-06-29       Impact factor: 6.150

4.  The von Economo neurons in apes and humans.

Authors:  John M Allman; Nicole A Tetreault; Atiya Y Hakeem; Soyoung Park
Journal:  Am J Hum Biol       Date:  2011 Jan-Feb       Impact factor: 1.937

Review 5.  Neuroscience in the era of functional genomics and systems biology.

Authors:  Daniel H Geschwind; Genevieve Konopka
Journal:  Nature       Date:  2009-10-15       Impact factor: 49.962

Review 6.  Renewed focus on the developing human neocortex.

Authors:  Gavin Clowry; Zoltán Molnár; Pasko Rakic
Journal:  J Anat       Date:  2010-10       Impact factor: 2.610

7.  Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.

Authors:  Achia Urbach; Ori Bar-Nur; George Q Daley; Nissim Benvenisty
Journal:  Cell Stem Cell       Date:  2010-05-07       Impact factor: 24.633

8.  Disease-specific induced pluripotent stem cells.

Authors:  In-Hyun Park; Natasha Arora; Hongguang Huo; Nimet Maherali; Tim Ahfeldt; Akiko Shimamura; M William Lensch; Chad Cowan; Konrad Hochedlinger; George Q Daley
Journal:  Cell       Date:  2008-08-07       Impact factor: 41.582

9.  Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

Authors:  Gabsang Lee; Eirini P Papapetrou; Hyesoo Kim; Stuart M Chambers; Mark J Tomishima; Christopher A Fasano; Yosif M Ganat; Jayanthi Menon; Fumiko Shimizu; Agnes Viale; Viviane Tabar; Michel Sadelain; Lorenz Studer
Journal:  Nature       Date:  2009-08-19       Impact factor: 49.962

10.  Direct conversion of fibroblasts to functional neurons by defined factors.

Authors:  Thomas Vierbuchen; Austin Ostermeier; Zhiping P Pang; Yuko Kokubu; Thomas C Südhof; Marius Wernig
Journal:  Nature       Date:  2010-01-27       Impact factor: 49.962
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  123 in total

Review 1.  CNVs: harbingers of a rare variant revolution in psychiatric genetics.

Authors:  Dheeraj Malhotra; Jonathan Sebat
Journal:  Cell       Date:  2012-03-16       Impact factor: 41.582

2.  Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders.

Authors:  Rui Luo; Stephan J Sanders; Yuan Tian; Irina Voineagu; Ni Huang; Su H Chu; Lambertus Klei; Chaochao Cai; Jing Ou; Jennifer K Lowe; Matthew E Hurles; Bernie Devlin; Matthew W State; Daniel H Geschwind
Journal:  Am J Hum Genet       Date:  2012-06-21       Impact factor: 11.025

Review 3.  Using Patient-Derived Induced Pluripotent Stem Cells to Model and Treat Epilepsies.

Authors:  Xixi Du; Jack M Parent
Journal:  Curr Neurol Neurosci Rep       Date:  2015-10       Impact factor: 5.081

Review 4.  Genetics and genomics of psychiatric disease.

Authors:  Daniel H Geschwind; Jonathan Flint
Journal:  Science       Date:  2015-09-24       Impact factor: 47.728

Review 5.  iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls.

Authors:  Daria Prilutsky; Nathan P Palmer; Niklas Smedemark-Margulies; Thorsten M Schlaeger; David M Margulies; Isaac S Kohane
Journal:  Trends Mol Med       Date:  2013-12-24       Impact factor: 11.951

Review 6.  Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?

Authors:  Cheryl Filippich; Ernst J Wolvetang; Bryan J Mowry
Journal:  Schizophr Bull       Date:  2013-07-24       Impact factor: 9.306

Review 7.  Peripheral biomarkers revisited: integrative profiling of peripheral samples for psychiatric research.

Authors:  Akiko Hayashi-Takagi; Marquis P Vawter; Kazuya Iwamoto
Journal:  Biol Psychiatry       Date:  2013-10-18       Impact factor: 13.382

8.  Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs).

Authors:  Madeline Williams; Smrithi Prem; Xiaofeng Zhou; Paul Matteson; Percy Luk Yeung; Chi-Wei Lu; Zhiping Pang; Linda Brzustowicz; James H Millonig; Emanuel Dicicco-Bloom
Journal:  J Vis Exp       Date:  2018-03-02       Impact factor: 1.355

9.  Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology.

Authors:  C Bardy; M van den Hurk; B Kakaradov; J A Erwin; B N Jaeger; R V Hernandez; T Eames; A A Paucar; M Gorris; C Marchand; R Jappelli; J Barron; A K Bryant; M Kellogg; R S Lasken; B P F Rutten; H W M Steinbusch; G W Yeo; F H Gage
Journal:  Mol Psychiatry       Date:  2016-10-04       Impact factor: 15.992

Review 10.  Modeling Huntington's disease with induced pluripotent stem cells.

Authors:  Julia A Kaye; Steven Finkbeiner
Journal:  Mol Cell Neurosci       Date:  2013-02-28       Impact factor: 4.314
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