| Literature DB >> 2166335 |
R M O'Brien1, P C Lucas, C D Forest, M A Magnuson, D K Granner.
Abstract
Phosphoenolpyruvate carboxykinase (PEPCK) governs the rate-limiting step in gluconeogenesis. Glucocorticoids and adenosine 3',5'-monophosphate (cAMP) increase PEPCK gene transcription and gluconeogenesis, whereas insulin has the opposite effect. Insulin is dominant, since it prevents cAMP and glucocorticoid-stimulated transcription. Glucocorticoid and cAMP response elements have been located in the PEPCK gene and now a 15-base pair insulin-responsive sequence (IRS) is described. Evidence for a binding activity that recognizes this sequence is presented.Entities:
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Year: 1990 PMID： 2166335 DOI： 10.1126/science.2166335
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728