Screening of a parallel combinatorial library for selectors for chiral chromatography.

A method to screen parallel combinatorial libraries for chiral selectors is described. Crucial elements to such an approach are the efficient syntheses of potential chiral selectors on synthesis resins and the rapid screening of selectors attached to these resins with circular dichroism measurement. The method does not require any immobilization of the analyte and could complement the mixture combinatorial library method developed earlier in this laboratory. The feasibility of this parallel library screening procedure is demonstrated with a model study of the chiral HPLC resolution of (1-naphthyl)leucine ester (1) using a 16-member small library.