Screening of mixture combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries.

An approach to screen mixture combinatorial libraries for chiral selectors is described. Crucial elements to such an approach are the reciprocity of chromatographic separation and the use of enantiomeric libraries. The feasibility of this method is demonstrated with a model study of the chiral resolution of (1-naphthyl)leucine ester 1 with a small peptide library.