Literature DB >> 2166240

Omegaconotoxin binding decreases in aged rat brain.

R M Moresco1, S Govoni, F Battaini, S Trivulzio, M Trabucchi.   

Abstract

Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding parameters were unmodified in hippocampus of the two age groups. These data are consistent with the decrease of calcium uptake and neurotransmitter release observed in the brain of aged rodents.

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Year:  1990        PMID： 2166240     DOI： 10.1016/0197-4580(90)90010-w

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  2 in total

1.  Chemical genetics reveals an RGS/G-protein role in the action of a compound.

Authors:  Kevin Fitzgerald; Svetlana Tertyshnikova; Lisa Moore; Lynn Bjerke; Ben Burley; Jian Cao; Pamela Carroll; Robert Choy; Steve Doberstein; Yves Dubaquie; Yvonne Franke; Jenny Kopczynski; Hendrik Korswagen; Stanley R Krystek; Nicholas J Lodge; Ronald Plasterk; John Starrett; Terry Stouch; George Thalody; Honey Wayne; Alexander van der Linden; Yongmei Zhang; Stephen G Walker; Mark Cockett; Judi Wardwell-Swanson; Petra Ross-Macdonald; Rachel M Kindt
Journal:  PLoS Genet       Date:  2006-04-21       Impact factor: 5.917

2.  Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis.

Authors:  Shasha Rao; Clive A Prestidge; Lynn Miesel; Deb Sweeney; Dean L Shinabarger; Ramiz A Boulos
Journal:  J Antibiot (Tokyo)       Date:  2016-05-18       Impact factor: 2.649
  2 in total

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