Literature DB >> 21660658

Cathepsin proteases in Toxoplasma gondii.

Zhicheng Dou1, Vern B Carruthers.   

Abstract

Cysteine proteases are important for the growth and survival of apicomplexan parasites that infect humans. The apicomplexan Toxoplasma gondii expresses five members of the C1 family of cysteine proteases, including one cathepsin L-like (TgCPL), one cathepsin B-like (TgCPB) and three cathepsin C-like (TgCPC1, 2 and 3) proteases. Recent genetic, biochemical and structural studies reveal that cathepsins function in microneme and rhoptry protein maturation, host cell invasion, replication and nutrient acquisition. here, we review the key features and roles of T. gondii cathepsins and discuss the therapeutic potential for specific inhibitor development.

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Year:  2011        PMID： 21660658      PMCID： PMC3953372          DOI： 10.1007/978-1-4419-8414-2_4

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  55 in total

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Authors:  S Håkansson; A J Charron; L D Sibley
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Authors:  S W Dahl; T Halkier; C Lauritzen; I Dolenc; J Pedersen; V Turk; B Turk
Journal:  Biochemistry       Date:  2001-02-13       Impact factor: 3.162

3.  Cysteine and serine protease inhibitors block intracellular development and disrupt the secretory pathway of Toxoplasma gondii.

Authors:  Michael K Shaw; David S Roos; Lewis G Tilney
Journal:  Microbes Infect       Date:  2002-02       Impact factor: 2.700

4.  Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases.

Authors:  D Turk; V Janjić; I Stern; M Podobnik; D Lamba; S W Dahl; C Lauritzen; J Pedersen; V Turk; B Turk
Journal:  EMBO J       Date:  2001-12-03       Impact factor: 11.598

5.  Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion.

Authors:  G Amuthan; G Biswas; S Y Zhang; A Klein-Szanto; C Vijayasarathy; N G Avadhani
Journal:  EMBO J       Date:  2001-04-17       Impact factor: 11.598

6.  Receptor-mediated endocytosis in an apicomplexan parasite (Toxoplasma gondii).

Authors:  S Botero-Kleiven; V Fernández; J Lindh; A Richter-Dahlfors; A von Euler; M Wahlgren
Journal:  Exp Parasitol       Date:  2001-07       Impact factor: 2.011

7.  TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2.

Authors:  K E Rabenau; A Sohrabi; A Tripathy; C Reitter; J W Ajioka; F M Tomley; V B Carruthers
Journal:  Mol Microbiol       Date:  2001-08       Impact factor: 3.501

8.  Proteasome inhibitors block intracellular growth and replication of Toxoplasma gondii.

Authors:  M K Shaw; C Y He; D S Roos; L G Tilney
Journal:  Parasitology       Date:  2000-07       Impact factor: 3.234

9.  Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii.

Authors:  S D Brydges; G D Sherman; S Nockemann; A Loyens; W Däubener; J F Dubremetz; V B Carruthers
Journal:  Mol Biochem Parasitol       Date:  2000-11       Impact factor: 1.759

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Authors:  C R Caffrey; E Hansell; K D Lucas; L S Brinen; A Alvarez Hernandez; J Cheng; S L Gwaltney; W R Roush; Y D Stierhof; M Bogyo; D Steverding; J H McKerrow
Journal:  Mol Biochem Parasitol       Date:  2001-11       Impact factor: 1.759
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  19 in total

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Authors:  Marie Schaeffer; Joerg Schroeder; Anja R Heckeroth; Sandra Noack; Michael Gassel; Jeremy C Mottram; Paul M Selzer; Graham H Coombs
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

2.  Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.

Authors:  Zhicheng Dou; Isabelle Coppens; Vern B Carruthers
Journal:  J Biol Chem       Date:  2012-12-18       Impact factor: 5.157

3.  Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii.

Authors:  Sally D Warring; Zhicheng Dou; Vern B Carruthers; Geoffrey I McFadden; Giel G van Dooren
Journal:  Eukaryot Cell       Date:  2014-05-23

4.  Secretion of Polypeptide Crystals from Tetrahymena thermophila Secretory Organelles (Mucocysts) Depends on Processing by a Cysteine Cathepsin, Cth4p.

Authors:  Santosh Kumar; Joseph S Briguglio; Aaron P Turkewitz
Journal:  Eukaryot Cell       Date:  2015-06-19

5.  Identification and characterization of a cathepsin L-like cysteine protease from Rhipicephalus (Boophilus) annulatus.

Authors:  Shahin Saidi; Sedighe Nabian; Elahe Ebrahimzade; Ali Najafi; Mehrdad Moosazadeh Moghaddam; Alireza Sazmand; Masoud Torkzadeh-Mahani; Saeed Sattari Tabrizi
Journal:  Exp Appl Acarol       Date:  2015-11-23       Impact factor: 2.132

6.  Identification and characterization of a cathepsin-L-like peptidase in Eimeria tenella.

Authors:  Renqiang Liu; Xueting Ma; Aijun Liu; Lei Zhang; Jianping Cai; Ming Wang
Journal:  Parasitol Res       Date:  2014-09-25       Impact factor: 2.289

7.  The mitochondrial genome and a 60-kb nuclear DNA segment from Naegleria fowleri, the causative agent of primary amoebic meningoencephalitis.

Authors:  Emily K Herman; Alexander L Greninger; Govinda S Visvesvara; Francine Marciano-Cabral; Joel B Dacks; Charles Y Chiu
Journal:  J Eukaryot Microbiol       Date:  2013-01-29       Impact factor: 3.346

8.  Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.

Authors:  Jeffery D Zwicker; David Smith; Alfredo J Guerra; Jacob R Hitchens; Nicole Haug; Steve Vander Roest; Pil Lee; Bo Wen; Duxin Sun; Lu Wang; Richard F Keep; Jianming Xiang; Vern B Carruthers; Scott D Larsen
Journal:  ACS Chem Neurosci       Date:  2020-02-18       Impact factor: 4.418

9.  Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis.

Authors:  Guanghui Zhao; Aihua Zhou; Gang Lv; Min Meng; Min Sun; Yang Bai; Yali Han; Lin Wang; Huaiyu Zhou; Hua Cong; Qunli Zhao; Xing-Quan Zhu; Shenyi He
Journal:  BMC Infect Dis       Date:  2013-05-07       Impact factor: 3.090

10.  Identification and characterization of Toxoplasma gondii aspartic protease 1 as a novel vaccine candidate against toxoplasmosis.

Authors:  Guanghui Zhao; Aihua Zhou; Gang Lu; Min Meng; Min Sun; Yang Bai; Yali Han; Lin Wang; Huaiyu Zhou; Hua Cong; Qunli Zhao; Xing-Quan Zhu; Shenyi He
Journal:  Parasit Vectors       Date:  2013-06-14       Impact factor: 3.876
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