OBJECTIVE: To evaluate the prevalence of RSV among hospitalized young children presenting with ALRI in Bangalore, India. METHODS: Respiratory syncytial virus (RSV) antigen detection was performed by direct fluorescent antibody (DFA) staining on 77 nasopharyngeal wash samples collected from hospitalized children below 2 years of age with a diagnosis of acute lower respiratory tract infection (ALRI). RESULTS: Out of 77 samples tested for RSV with DFA, 17 (22.1%) were found RSV-positive with a mean age of 8.24 ± 7.21 months (M:F = 1.8:1). Three children had congenital cardiac disease and one child had a history of prematurity. One child had re-infection within one month of primary infection. RSV-infected children were more likely to have a diagnosis of bronchiolitis than RSV-negative children (p < 0.001). CONCLUSIONS: RSV infection is a significant cause of morbidity among children presenting with ALRI in southern India. In resource-limited settings, DFA can be used as an important tool for rapid detection of RSV and can potentially eliminate prolonged hospitalization and unnecessary use of antibiotics.
OBJECTIVE: To evaluate the prevalence of RSV among hospitalized young children presenting with ALRI in Bangalore, India. METHODS:Respiratory syncytial virus (RSV) antigen detection was performed by direct fluorescent antibody (DFA) staining on 77 nasopharyngeal wash samples collected from hospitalized children below 2 years of age with a diagnosis of acute lower respiratory tract infection (ALRI). RESULTS: Out of 77 samples tested for RSV with DFA, 17 (22.1%) were found RSV-positive with a mean age of 8.24 ± 7.21 months (M:F = 1.8:1). Three children had congenital cardiac disease and one child had a history of prematurity. One child had re-infection within one month of primary infection. RSV-infectedchildren were more likely to have a diagnosis of bronchiolitis than RSV-negative children (p < 0.001). CONCLUSIONS:RSV infection is a significant cause of morbidity among children presenting with ALRI in southern India. In resource-limited settings, DFA can be used as an important tool for rapid detection of RSV and can potentially eliminate prolonged hospitalization and unnecessary use of antibiotics.
Authors: Anurodh S Agrawal; Mehuli Sarkar; Sekhar Chakrabarti; K Rajendran; Harpreet Kaur; Akhilesh C Mishra; Mrinal K Chatterjee; Trailokya N Naik; Mandeep S Chadha; Mamta Chawla-Sarkar Journal: J Med Microbiol Date: 2009-08-27 Impact factor: 2.472
Authors: Caroline Breese Hall; Geoffrey A Weinberg; Marika K Iwane; Aaron K Blumkin; Kathryn M Edwards; Mary A Staat; Peggy Auinger; Marie R Griffin; Katherine A Poehling; Dean Erdman; Carlos G Grijalva; Yuwei Zhu; Peter Szilagyi Journal: N Engl J Med Date: 2009-02-05 Impact factor: 91.245