Literature DB >> 21660053

Expanding TRAF function: TRAF3 as a tri-faced immune regulator.

Hans Häcker1, Ping-Hui Tseng, Michael Karin.   

Abstract

Tumour necrosis factor receptor (TNFR)-associated factor (TRAF) proteins are essential components of signalling pathways activated by TNFR or Toll-like receptor (TLR) family members. Acting alone or in combination, the seven known TRAFs control many biological processes, including cytokine production and cell survival. The function of one TRAF in particular, TRAF3, remained elusive for many years. Recent work has revealed that TRAF3 is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein kinase activation and alternative nuclear factor-κB signalling. In this Review, we discuss our current understanding of the role of TRAF3 in TNFR and TLR signalling pathways, and its role in disease.

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Year:  2011        PMID： 21660053     DOI： 10.1038/nri2998

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  92 in total

Review 1.  Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.

Authors:  M Karin; Y Ben-Neriah
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

Review 2.  The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.

Authors:  Taro Kawai; Shizuo Akira
Journal:  Nat Immunol       Date:  2010-04-20       Impact factor: 25.606

Review 3.  Toll-like receptor and RIG-I-like receptor signaling.

Authors:  Taro Kawai; Shizuo Akira
Journal:  Ann N Y Acad Sci       Date:  2008-11       Impact factor: 5.691

4.  A novel RING finger protein interacts with the cytoplasmic domain of CD40.

Authors:  H M Hu; K O'Rourke; M S Boguski; V M Dixit
Journal:  J Biol Chem       Date:  1994-12-02       Impact factor: 5.157

5.  Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling.

Authors:  Jin Gohda; Takayuki Matsumura; Jun-ichiro Inoue
Journal:  J Immunol       Date:  2004-09-01       Impact factor: 5.422

6.  Control of canonical NF-kappaB activation through the NIK-IKK complex pathway.

Authors:  Brian Zarnegar; Soh Yamazaki; Jeannie Q He; Genhong Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-21       Impact factor: 11.205

7.  TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.

Authors:  Jonathan C Kagan; Tian Su; Tiffany Horng; Amy Chow; Shizuo Akira; Ruslan Medzhitov
Journal:  Nat Immunol       Date:  2008-02-24       Impact factor: 25.606

8.  TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.

Authors:  Sandra Gardam; Frederic Sierro; Antony Basten; Fabienne Mackay; Robert Brink
Journal:  Immunity       Date:  2008-02-28       Impact factor: 31.745

9.  Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.

Authors:  Christina M Annunziata; R Eric Davis; Yulia Demchenko; William Bellamy; Ana Gabrea; Fenghuang Zhan; Georg Lenz; Ichiro Hanamura; George Wright; Wenming Xiao; Sandeep Dave; Elaine M Hurt; Bruce Tan; Hong Zhao; Owen Stephens; Madhumita Santra; David R Williams; Lenny Dang; Bart Barlogie; John D Shaughnessy; W Michael Kuehl; Louis M Staudt
Journal:  Cancer Cell       Date:  2007-08       Impact factor: 31.743

Review 10.  A cell biological view of Toll-like receptor function: regulation through compartmentalization.

Authors:  Gregory M Barton; Jonathan C Kagan
Journal:  Nat Rev Immunol       Date:  2009-06-26       Impact factor: 53.106
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  186 in total

1.  Vasoactive intestinal peptide downregulates proinflammatory TLRs while upregulating anti-inflammatory TLRs in the infected cornea.

Authors:  Xiaoyu Jiang; Sharon A McClellan; Ronald P Barrett; Yunfan Zhang; Linda D Hazlett
Journal:  J Immunol       Date:  2012-06-01       Impact factor: 5.422

2.  TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy.

Authors:  Zhangguo Chen; Alexandra Krinsky; Rachel A Woolaver; Xiaoguang Wang; Samantha M Y Chen; Vince Popolizio; Ping Xie; Jing H Wang
Journal:  J Immunol       Date:  2020-06-26       Impact factor: 5.422

3.  The overlapping host responses to bacterial cyclic dinucleotides.

Authors:  Ali A Abdul-Sater; Andrzej Grajkowski; Hediye Erdjument-Bromage; Courtney Plumlee; Assaf Levi; Michael T Schreiber; Carolyn Lee; Howard Shuman; Serge L Beaucage; Christian Schindler
Journal:  Microbes Infect       Date:  2011-09-10       Impact factor: 2.700

Review 4.  NF-κB, the first quarter-century: remarkable progress and outstanding questions.

Authors:  Matthew S Hayden; Sankar Ghosh
Journal:  Genes Dev       Date:  2012-02-01       Impact factor: 11.361

5.  Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5.

Authors:  Glenna Wink Foight; Amy E Keating
Journal:  Protein Sci       Date:  2016-02-03       Impact factor: 6.725

6.  The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

Authors:  Hiroyuki Nagashima; Yuko Okuyama; Atsuko Asao; Takeshi Kawabe; Satoshi Yamaki; Hiroyasu Nakano; Michael Croft; Naoto Ishii; Takanori So
Journal:  Nat Immunol       Date:  2014-03-30       Impact factor: 25.606

7.  A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway.

Authors:  Emine Guven-Maiorov; Ozlem Keskin; Attila Gursoy; Ruth Nussinov
Journal:  Biophys J       Date:  2015-08-11       Impact factor: 4.033

Review 8.  Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K.

Authors:  Ty Dale Troutman; J Fernando Bazan; Chandrashekhar Pasare
Journal:  Cell Cycle       Date:  2012-08-16       Impact factor: 4.534

9.  Structural Insights into mitochondrial antiviral signaling protein (MAVS)-tumor necrosis factor receptor-associated factor 6 (TRAF6) signaling.

Authors:  Zhubing Shi; Zhen Zhang; Zhenzhen Zhang; Yanyan Wang; Chuanchuan Li; Xin Wang; Feng He; Lina Sun; Shi Jiao; Weiyang Shi; Zhaocai Zhou
Journal:  J Biol Chem       Date:  2015-09-18       Impact factor: 5.157

10.  Mint3 potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune responses.

Authors:  Wanwan Huai; Hui Song; Zhongxia Yu; Wenwen Wang; Lihui Han; Takeharu Sakamoto; Motoharu Seiki; Lining Zhang; Qunye Zhang; Wei Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-03       Impact factor: 11.205
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