Yvonne Nussbaumer-Ochsner1, Tsogyal D Latshang1, Silvia Ulrich1, Malcolm Kohler2, Robert Thurnheer3, Konrad E Bloch4. 1. Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Zurich; Center for Human Integrative Physiology, University of Zurich, Zurich. 2. Center for Human Integrative Physiology, University of Zurich, Zurich. 3. Pulmonary Division, Cantonal Hospital Munsterlingen, Munsterlingen, Switzerland. 4. Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Zurich; Center for Human Integrative Physiology, University of Zurich, Zurich. Electronic address: konrad.bloch@usz.ch.
Abstract
BACKGROUND: Many patients with obstructive sleep apnea syndrome (OSA) are unable or unwilling to use continuous positive airway pressure (CPAP) therapy when traveling to the mountains for work or recreation even though they risk pronounced hypoxemia and exacerbation of sleep apnea. Because the treatment of OSA at altitude has not been established, we tested the hypothesis that acetazolamide improves hypoxemia, sleep, and breathing disturbances in otherwise untreated patients with OSA at altitude. METHODS:Forty-five patients with OSA on long-term CPAP, median age 64 years, living at <; 600 m underwent a placebo-controlled, double-blind, crossover trial randomized for the sequence of drug and altitude exposure (490 m, 1,860 m, and 2,590 m). Patients spent two 3-day periods at altitude and a 2-week wash-out period at < 600 m. At altitude, patients discontinued CPAP and received acetazolamide 2 × 250 mg daily or placebo. Polysomnography, vigilance, and symptoms were evaluated. RESULTS: At 490 m, off CPAP, median nocturnal oxygen saturation was 93%, and the apnea/hypopnea index was 51.2/h. On placebo at 1,860 m and 2,590 m, the corresponding values were 89% and 85% and 63.6/h and 86.2/h, respectively (P < .01 vs 490 m, both instances). On acetazolamide at 1,860 m and 2,590 m, oxygen saturation was higher (91% and 88%) and apnea/hypopnea indices were lower (48.0/h and 61.4/h) than on placebo (P < .01 all instances). Acetazolamide reduced nocturnal transcutaneous Pco(2), improved sleep efficiency and subjective insomnia, and prevented excessive BP elevations at altitude. CONCLUSIONS: In patients with OSA discontinuing CPAP during an altitude sojourn, acetazolamide improves oxygenation, breathing disturbances, and sleep quality by stimulating ventilation. Therefore, patients with OSA may benefit from acetazolamide at altitude if CPAP therapy is not feasible. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00714740; URL: www.clinicaltrials.gov.
RCT Entities:
BACKGROUND: Many patients with obstructive sleep apnea syndrome (OSA) are unable or unwilling to use continuous positive airway pressure (CPAP) therapy when traveling to the mountains for work or recreation even though they risk pronounced hypoxemia and exacerbation of sleep apnea. Because the treatment of OSA at altitude has not been established, we tested the hypothesis that acetazolamide improves hypoxemia, sleep, and breathing disturbances in otherwise untreated patients with OSA at altitude. METHODS: Forty-five patients with OSA on long-term CPAP, median age 64 years, living at < 600 m underwent a placebo-controlled, double-blind, crossover trial randomized for the sequence of drug and altitude exposure (490 m, 1,860 m, and 2,590 m). Patients spent two 3-day periods at altitude and a 2-week wash-out period at < 600 m. At altitude, patients discontinued CPAP and received acetazolamide 2 × 250 mg daily or placebo. Polysomnography, vigilance, and symptoms were evaluated. RESULTS: At 490 m, off CPAP, median nocturnal oxygen saturation was 93%, and the apnea/hypopnea index was 51.2/h. On placebo at 1,860 m and 2,590 m, the corresponding values were 89% and 85% and 63.6/h and 86.2/h, respectively (P < .01 vs 490 m, both instances). On acetazolamide at 1,860 m and 2,590 m, oxygen saturation was higher (91% and 88%) and apnea/hypopnea indices were lower (48.0/h and 61.4/h) than on placebo (P < .01 all instances). Acetazolamide reduced nocturnal transcutaneous Pco(2), improved sleep efficiency and subjective insomnia, and prevented excessive BP elevations at altitude. CONCLUSIONS: In patients with OSA discontinuing CPAP during an altitude sojourn, acetazolamide improves oxygenation, breathing disturbances, and sleep quality by stimulating ventilation. Therefore, patients with OSA may benefit from acetazolamide at altitude if CPAP therapy is not feasible. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00714740; URL: www.clinicaltrials.gov.
Authors: John B Tanner; Sarah M E Tanner; Ghan Bahadur Thapa; Yuchiao Chang; Kirsty L M Watson; Eamon Staunton; Claire Howarth; Buddha Basnyat; N Stuart Harris Journal: High Alt Med Biol Date: 2013-09-12 Impact factor: 1.981
Authors: Tsogyal D Latshang; Christian M Lo Cascio; Anne-Christin Stöwhas; Mirjam Grimm; Katrin Stadelmann; Noemi Tesler; Peter Achermann; Reto Huber; Malcolm Kohler; Konrad E Bloch Journal: Sleep Date: 2013-12-01 Impact factor: 5.849