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Literature DB >> 2165915

Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques.

L Janzen¹, W W Tourtellotte, J N Kanfer.

Abstract

Glycerylphosphorylcholine (GPC) phosphocholine phosphodiesterase activity (EC 3.1.4.38) is significantly reduced in multiple sclerosis plaques compared to adjacent tissue with a P less than 0.01 based upon the Student-Newman-Keuls or Tukey test. This finding is in accord with the proposal that this particular form of the enzyme is myelin-specific. Similar activities for GPC phosphocholine phosphodiesterase were obtained with samples from various regions of the same individual brain.

Entities: Disease

Mesh：

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Year: 1990 PMID： 2165915 DOI： 10.1016/0014-4886(90)90079-8

Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330

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Cited

9 in total

1. Characterization of a Zn(2+)-requiring glycerophosphocholine cholinephosphodiesterase possessing p-nitrophenylphosphocholine phosphodiesterase activity.

Authors: D E Sok; M R Kim
Journal: Biochem J Date: 1992-09-01 Impact factor: 3.857

2. Properties of a Zn(2+)-glycerophosphocholine cholinephosphodiesterase from bovine brain membranes.

Authors: D E Sok
Journal: Neurochem Res Date: 1996-10 Impact factor: 3.996

3. Bovine brain myelin glycerophosphocholine choline phosphodiesterase is an alkaline lysosphingomyelinase of the eNPP-family, regulated by lysosomal sorting.

Authors: Linn Greiner-Tollersrud; Thomas Berg; Hilde M F R Stensland; Gry Evjen; Ole K Greiner-Tollersrud
Journal: Neurochem Res Date: 2012-11-17 Impact factor: 3.996

8. Involvement of both a Zn2+ site and an anionic binding site in the selective inhibition of a Zn(2+)-glycerophosphocholine cholinephosphodiesterase by thiols and tellurites.

Authors: D E Sok; M R Kim
Journal: Neurochem Res Date: 1995-02 Impact factor: 3.996

9. Multiple forms of the enzyme glycerophosphodiesterase are present in human brain.

Authors: B M Ross; A L Sherwin; S J Kish
Journal: Lipids Date: 1995-12 Impact factor: 1.880

9 in total

Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques.

1. Characterization of a Zn(2+)-requiring glycerophosphocholine cholinephosphodiesterase possessing p-nitrophenylphosphocholine phosphodiesterase activity.

2. Properties of a Zn(2+)-glycerophosphocholine cholinephosphodiesterase from bovine brain membranes.

3. Bovine brain myelin glycerophosphocholine choline phosphodiesterase is an alkaline lysosphingomyelinase of the eNPP-family, regulated by lysosomal sorting.

4. Interaction of divalent metal ions with Zn(2+)-glycerophosphocholine cholinephosphodiesterase from ox brain.

5. Oxidative inactivation of brain ecto-5'-nucleotidase by thiols/Fe2+ system.

6. Active site of brain Zn2+-glycerophosphocholine cholinephosphodiesterase and regulation of enzyme activity.

7. Purification and properties of a glycerophosphocholine phosphodiesterase from bovine brain myelin.

8. Involvement of both a Zn2+ site and an anionic binding site in the selective inhibition of a Zn(2+)-glycerophosphocholine cholinephosphodiesterase by thiols and tellurites.

9. Multiple forms of the enzyme glycerophosphodiesterase are present in human brain.