OBJECTIVES: To determine whether there is a relationship between electroencephalography patterns and hypoglycemia, by using simultaneous cot-side amplitude integrated electroencephalography (aEEG) and continuous interstitial glucose monitoring, and whether non-glucose cerebral fuels modified these patterns. STUDY DESIGN: Eligible babies were ≥ 32 weeks gestation, at risk for hypoglycemia, and admitted to the neonatal intensive care unit. Electrodes were placed in C3-P3, C4-P4 O1-O2 montages. A continuous interstitial glucose sensor was placed subcutaneously, and blood glucose was measured by using the glucose oxidase method. Non-glucose cerebral fuels were measured at study entry, exit, and during recognized hypoglycemia. RESULTS: A total of 101 babies were enrolled, with a median weight of 2179 g and gestation of 35 weeks. Twenty-four of the babies had aEEG recordings, and glucose concentrations were low (< 2.6 mM). There were 103 episodes of low glucose concentrations lasting 5 to 475 minutes, but no observable changes in aEEG variables. Plasma concentrations of lactate, beta-hydroxybutyrate, and glycerol were low and did not alter during hypoglycemia. CONCLUSIONS: Cot-side aEEG was not useful for the detection of neurological changes during mild hypoglycemia. Plasma concentrations of non-glucose cerebral fuels were low and unlikely to provide substantial neuroprotection.
OBJECTIVES: To determine whether there is a relationship between electroencephalography patterns and hypoglycemia, by using simultaneous cot-side amplitude integrated electroencephalography (aEEG) and continuous interstitial glucose monitoring, and whether non-glucose cerebral fuels modified these patterns. STUDY DESIGN: Eligible babies were ≥ 32 weeks gestation, at risk for hypoglycemia, and admitted to the neonatal intensive care unit. Electrodes were placed in C3-P3, C4-P4 O1-O2 montages. A continuous interstitial glucose sensor was placed subcutaneously, and blood glucose was measured by using the glucose oxidase method. Non-glucose cerebral fuels were measured at study entry, exit, and during recognized hypoglycemia. RESULTS: A total of 101 babies were enrolled, with a median weight of 2179 g and gestation of 35 weeks. Twenty-four of the babies had aEEG recordings, and glucose concentrations were low (< 2.6 mM). There were 103 episodes of low glucose concentrations lasting 5 to 475 minutes, but no observable changes in aEEG variables. Plasma concentrations of lactate, beta-hydroxybutyrate, and glycerol were low and did not alter during hypoglycemia. CONCLUSIONS: Cot-side aEEG was not useful for the detection of neurological changes during mild hypoglycemia. Plasma concentrations of non-glucose cerebral fuels were low and unlikely to provide substantial neuroprotection.
Authors: Christopher J D McKinlay; Jane M Alsweiler; Judith M Ansell; Nicola S Anstice; J Geoffrey Chase; Gregory D Gamble; Deborah L Harris; Robert J Jacobs; Yannan Jiang; Nabin Paudel; Matthew Signal; Benjamin Thompson; Trecia A Wouldes; Tzu-Ying Yu; Jane E Harding Journal: N Engl J Med Date: 2015-10-15 Impact factor: 91.245
Authors: Rajesh Shah; Darren W T Dai; Jane M Alsweiler; Gavin T L Brown; J Geoffrey Chase; Gregory D Gamble; Deborah L Harris; Peter Keegan; Samson Nivins; Trecia A Wouldes; Benjamin Thompson; Jason Turuwhenua; Jane E Harding; Christopher J D McKinlay Journal: JAMA Date: 2022-03-22 Impact factor: 157.335
Authors: Benjamin Thompson; Christopher J D McKinlay; Arijit Chakraborty; Nicola S Anstice; Robert J Jacobs; Nabin Paudel; Tzu-Ying Yu; Judith M Ansell; Trecia A Wouldes; Jane E Harding Journal: Neurosci Lett Date: 2017-08-31 Impact factor: 3.046