BACKGROUND: Radiation-induced angiosarcoma (RA) is a well-recognized complication of breast conservation therapy (BCT). METHODS: Over a 12-year period, 14 patients with a median age of 68 years were identified retrospectively. The median latency from BCT to onset of RA was 81 months. The incomplete excision rate (complete histologic margin taken to be > 10 mm) was 46%. There was a significant difference in the size of the cutaneous defect between the complete and incomplete excision groups (412 vs 592 cm(2), respectively; P < .05), indicating more extensive disease in the latter group. RESULTS: The tumor recurred locally in 12 patients (92%). The median time to local recurrence (LR) in patients with incomplete excision was 3 versus 23 months in patients who had a complete excision. The median survival time for patients who underwent complete versus incomplete excision was 42 and 6 months, respectively. CONCLUSIONS: RA is a challenging condition, with a prolonged latency period and variable clinical progression. Incomplete excision of RA is a surrogate marker of aggressive disease and is associated with rapid LR and poor survival.
BACKGROUND: Radiation-induced angiosarcoma (RA) is a well-recognized complication of breast conservation therapy (BCT). METHODS: Over a 12-year period, 14 patients with a median age of 68 years were identified retrospectively. The median latency from BCT to onset of RA was 81 months. The incomplete excision rate (complete histologic margin taken to be > 10 mm) was 46%. There was a significant difference in the size of the cutaneous defect between the complete and incomplete excision groups (412 vs 592 cm(2), respectively; P < .05), indicating more extensive disease in the latter group. RESULTS: The tumor recurred locally in 12 patients (92%). The median time to local recurrence (LR) in patients with incomplete excision was 3 versus 23 months in patients who had a complete excision. The median survival time for patients who underwent complete versus incomplete excision was 42 and 6 months, respectively. CONCLUSIONS:RA is a challenging condition, with a prolonged latency period and variable clinical progression. Incomplete excision of RA is a surrogate marker of aggressive disease and is associated with rapid LR and poor survival.
Authors: Matthew C Perez; Tapan A Padhya; Jane L Messina; Ryan S Jackson; Ricardo J Gonzalez; Marilyn M Bui; G Douglas Letson; C W Cruse; Robert S Lavey; David Cheong; Meghan R Forster; William J Fulp; Vernon K Sondak; Jonathan S Zager Journal: Ann Surg Oncol Date: 2013-07-09 Impact factor: 5.344
Authors: M Linthorst; A N van Geel; E A Baartman; S B Oei; W Ghidey; G C van Rhoon; J van der Zee Journal: Strahlenther Onkol Date: 2013-04-04 Impact factor: 3.621
Authors: Jojanneke M Seinen; Emelie Styring; Vincent Verstappen; Fredrik Vult von Steyern; Anders Rydholm; Albert J H Suurmeijer; Harald J Hoekstra Journal: Ann Surg Oncol Date: 2012-03-31 Impact factor: 5.344
Authors: R B Cohen-Hallaleh; H G Smith; R C Smith; G F Stamp; O Al-Muderis; K Thway; A Miah; K Khabra; I Judson; R Jones; C Benson; A J Hayes Journal: Clin Sarcoma Res Date: 2017-08-07
Authors: Juan R Mella; Kimberly M Ross; George Z Li; Bohdan Pomahac; Chandrajit P Raut; Dennis P Orgill Journal: Plast Reconstr Surg Glob Open Date: 2018-09-05