OBJECTIVE: The objective of the study was to investigate the association of maternal vitamin D and maternal asthma and infant respiratory infection severity. STUDY DESIGN: The study included cross-sectional analyses of 340 mother-infant dyads enrolled from September to May 2004-2008 during an infant viral respiratory infection. Maternal vitamin D levels were determined from enrollment blood specimens. At enrollment, we determined self-reported maternal asthma and infant respiratory infection severity using a bronchiolitis score. We assessed the association of maternal vitamin D levels and maternal asthma and infant bronchiolitis score in race-stratified multivariable regression models. RESULTS: The cohort was 70% white, 19% African American, and 21% had asthma. Overall, the median maternal vitamin D level was 20 ng/mL (interquartile range, 14-28). Among white women, a 14 ng/mL increase in vitamin D was associated with a decreased odds of asthma (adjusted odds ratio, 0.54; 95% confidence interval, 0.33-0.86). Maternal vitamin D was not associated with infant bronchiolitis score. CONCLUSION: Higher maternal vitamin D levels were associated with decreased odds of asthma.
OBJECTIVE: The objective of the study was to investigate the association of maternal vitamin D and maternal asthma and infantrespiratory infection severity. STUDY DESIGN: The study included cross-sectional analyses of 340 mother-infant dyads enrolled from September to May 2004-2008 during an infantviral respiratory infection. Maternal vitamin D levels were determined from enrollment blood specimens. At enrollment, we determined self-reported maternal asthma and infantrespiratory infection severity using a bronchiolitis score. We assessed the association of maternal vitamin D levels and maternal asthma and infantbronchiolitis score in race-stratified multivariable regression models. RESULTS: The cohort was 70% white, 19% African American, and 21% had asthma. Overall, the median maternal vitamin D level was 20 ng/mL (interquartile range, 14-28). Among white women, a 14 ng/mL increase in vitamin D was associated with a decreased odds of asthma (adjusted odds ratio, 0.54; 95% confidence interval, 0.33-0.86). Maternal vitamin D was not associated with infantbronchiolitis score. CONCLUSION: Higher maternal vitamin D levels were associated with decreased odds of asthma.
Authors: Yueh-Ying Han; Josh Blatter; John M Brehm; Erick Forno; Augusto A Litonjua; Juan C Celedón Journal: Lancet Respir Med Date: 2013-07-31 Impact factor: 30.700
Authors: Kecia N Carroll; Tebeb Gebretsadik; Patricia Minton; Kimberly Woodward; Zhouwen Liu; E Kathryn Miller; John V Williams; William D Dupont; Tina V Hartert Journal: J Allergy Clin Immunol Date: 2012-02-14 Impact factor: 10.793
Authors: Pingsheng Wu; Emma K Larkin; Sara S Reiss; Kecia N Carroll; Marshall L Summar; Patricia A Minton; Kimberly B Woodward; Zhouwen Liu; Jessica Y Islam; Tina V Hartert; Paul E Moore Journal: BMC Med Genet Date: 2015-09-14 Impact factor: 2.103