OBJECTIVE: The aim of this study was to systematically review the relationship between amphetamine exposure in pregnancy and birth outcomes. STUDY DESIGN: Electronic databases were searched to identify relevant studies. Data from included studies were extracted by 2 reviewers. Summary odds ratio (OR) and confidence intervals (CIs) were calculated using the random effects model. RESULTS: Ten studies were included. Significant increases in unadjusted risks of preterm birth (OR, 4.11; 95% CI, 3.05-5.55), low birthweight (OR, 3.97; 95% CI, 2.45-6.43), and small for gestational age (OR, 5.79; 95% CI, 1.39-24.06) were identified among women exposed to amphetamines in pregnancy. The mean birthweight was significantly lower among amphetamine-exposed pregnancies (mean difference, -279 g; 95% CI, -485 to -74 g). Two studies provided adjusted estimates on different outcomes, and their results were consistent with the findings from the unadjusted data. CONCLUSION: Amphetamine exposure in pregnancy is associated with adverse birth outcomes and should be identified by physicians providing antenatal care.
OBJECTIVE: The aim of this study was to systematically review the relationship between amphetamine exposure in pregnancy and birth outcomes. STUDY DESIGN: Electronic databases were searched to identify relevant studies. Data from included studies were extracted by 2 reviewers. Summary odds ratio (OR) and confidence intervals (CIs) were calculated using the random effects model. RESULTS: Ten studies were included. Significant increases in unadjusted risks of preterm birth (OR, 4.11; 95% CI, 3.05-5.55), low birthweight (OR, 3.97; 95% CI, 2.45-6.43), and small for gestational age (OR, 5.79; 95% CI, 1.39-24.06) were identified among women exposed to amphetamines in pregnancy. The mean birthweight was significantly lower among amphetamine-exposed pregnancies (mean difference, -279 g; 95% CI, -485 to -74 g). Two studies provided adjusted estimates on different outcomes, and their results were consistent with the findings from the unadjusted data. CONCLUSION:Amphetamine exposure in pregnancy is associated with adverse birth outcomes and should be identified by physicians providing antenatal care.
Authors: Lindsay K Admon; Gavin Bart; Katy B Kozhimannil; Caroline R Richardson; Vanessa K Dalton; Tyler N A Winkelman Journal: Am J Public Health Date: 2018-11-29 Impact factor: 9.308
Authors: Fleur L Warton; Ernesta M Meintjes; Christopher M R Warton; Christopher D Molteno; Nadine M Lindinger; R Colin Carter; Lilla Zöllei; Pia Wintermark; Joseph L Jacobson; Andre van der Kouwe; Sandra W Jacobson Journal: Neurotoxicol Teratol Date: 2017-10-22 Impact factor: 3.763
Authors: Fleur L Warton; Paul A Taylor; Christopher M R Warton; Christopher D Molteno; Pia Wintermark; Nadine M Lindinger; Lilla Zöllei; Andre van der Kouwe; Joseph L Jacobson; Sandra W Jacobson; Ernesta M Meintjes Journal: Metab Brain Dis Date: 2017-10-23 Impact factor: 3.584