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Literature DB >> 21658599

The SirT3 divining rod points to oxidative stress.

Abstract

Sirtuins are NAD(+) dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 to management of reactive oxygen species from mitochondria, which may have profound implications for aging and late-onset diseases.

Entities: CellLine Chemical Disease Gene Species

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Year: 2011 PMID： 21658599 PMCID： PMC3526939 DOI： 10.1016/j.molcel.2011.05.008

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

78 in total

1. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

Authors: Randa Tao; Mitchell C Coleman; J Daniel Pennington; Ozkan Ozden; Seong-Hoon Park; Haiyan Jiang; Hyun-Seok Kim; Charles Robb Flynn; Salisha Hill; W Hayes McDonald; Alicia K Olivier; Douglas R Spitz; David Gius
Journal: Mol Cell Date: 2010-12-22 Impact factor: 17.970

2. SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity.

Authors: Jianjun Bao; Iain Scott; Zhongping Lu; Liyan Pang; Christopher C Dimond; David Gius; Michael N Sack
Journal: Free Radic Biol Med Date: 2010-07-18 Impact factor: 7.376

3. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.

Authors: Shinichi Someya; Wei Yu; William C Hallows; Jinze Xu; James M Vann; Christiaan Leeuwenburgh; Masaru Tanokura; John M Denu; Tomas A Prolla
Journal: Cell Date: 2010-11-24 Impact factor: 41.582

Review 4. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.

Authors: Eric Verdin; Matthew D Hirschey; Lydia W S Finley; Marcia C Haigis
Journal: Trends Biochem Sci Date: 2010-09-20 Impact factor: 13.807

5. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.

Authors: William C Hallows; Wei Yu; Brian C Smith; Mark K Devries; Mark K Devires; James J Ellinger; Shinichi Someya; Michael R Shortreed; Tomas Prolla; John L Markley; Lloyd M Smith; Shimin Zhao; Kun-Liang Guan; John M Denu
Journal: Mol Cell Date: 2011-01-21 Impact factor: 17.970

6. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Authors: Tadahiro Shimazu; Matthew D Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David B Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
Journal: Cell Metab Date: 2010-12-01 Impact factor: 27.287

7. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.

Authors: Xiaolei Qiu; Katharine Brown; Matthew D Hirschey; Eric Verdin; Danica Chen
Journal: Cell Metab Date: 2010-12-01 Impact factor: 27.287

Review 8. SIRT1: recent lessons from mouse models.

Authors: Daniel Herranz; Manuel Serrano
Journal: Nat Rev Cancer Date: 2010-11-24 Impact factor: 60.716

Review 9. Hypoxia-inducible factors and the response to hypoxic stress.

Authors: Amar J Majmundar; Waihay J Wong; M Celeste Simon
Journal: Mol Cell Date: 2010-10-22 Impact factor: 17.970

10. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.

Authors: Angela V Hafner; Jing Dai; Ana P Gomes; Chun-Yang Xiao; Carlos M Palmeira; Anthony Rosenzweig; David A Sinclair
Journal: Aging (Albany NY) Date: 2010-12 Impact factor: 5.682

105 in total

Review 1. Sirtuins mediate mammalian metabolic responses to nutrient availability.

Authors: Angeliki Chalkiadaki; Leonard Guarente
Journal: Nat Rev Endocrinol Date: 2012-01-17 Impact factor: 43.330

2. Metabolic signals regulate SIRT1 expression.

Authors: Angeliki Chalkiadaki; Leonard Guarente
Journal: EMBO Rep Date: 2011-09-30 Impact factor: 8.807

Review 3. Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart.

Authors: Michael N Sack
Journal: Am J Physiol Heart Circ Physiol Date: 2011-10-07 Impact factor: 4.733

4. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.

Authors: Kristofer S Fritz; James J Galligan; Matthew D Hirschey; Eric Verdin; Dennis R Petersen
Journal: J Proteome Res Date: 2012-02-21 Impact factor: 4.466

5. trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.

Authors: Jinrong Fu; Jing Jin; Robert H Cichewicz; Serena A Hageman; Trevor K Ellis; Lan Xiang; Qi Peng; Mali Jiang; Nicolas Arbez; Katelyn Hotaling; Christopher A Ross; Wenzhen Duan
Journal: J Biol Chem Date: 2012-05-30 Impact factor: 5.157

6. PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β.

Authors: Xuefei Zhang; Xiaoqing Ren; Qi Zhang; Zheyi Li; Shuaipeng Ma; Jintao Bao; Zeyang Li; Xue Bai; Liangjun Zheng; Zhong Zhang; Shujiang Shang; Chen Zhang; Chuangui Wang; Liu Cao; Qingsong Wang; Jianguo Ji
Journal: Antioxid Redox Signal Date: 2015-11-19 Impact factor: 8.401