| Literature DB >> 21658598 |
Abstract
Mulligan et al. (2011) show here that the NAD(+)-dependent SIRT1 (H4K16; H1K26) deacetylase acts in concert with the LSD1 (H3K4) demethylase to repress Notch-induced transcription, thus coupling two distinct histone modifications at a key epigenetic switch for Notch target genes.Entities:
Year: 2011 PMID: 21658598 PMCID: PMC3491984 DOI: 10.1016/j.molcel.2011.05.017
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970