Literature DB >> 216571

Naloxone and intestinal motility.

R A Howd, A Adamovics, A Palekar.   

Abstract

It was supposed that the inhibition of intestinal peristalsis seen in animals and humans after abdominal surgery might be related to the release of endorphins, endogenous opiate receptor agonists, caused by the surgical stress and pain. However, naloxone, a potent morphine and endorphin antagonist, failed to block this peristaltic inhibition in rats, which leaves the mechanism of this inhibition, and thus the function of intestinal endorphins, still very much in doubt.

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Year:  1978        PMID: 216571     DOI: 10.1007/bf01981437

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  11 in total

1.  In vitro pharmacology of the opioid peptides, enkephalins and endorphins.

Authors:  A A Waterfield; R W Smokcum; J Hughes; H W Kosterlitz; G Henderson
Journal:  Eur J Pharmacol       Date:  1977-05-15       Impact factor: 4.432

2.  Purification and properties of enkephalin - the possible endogenous ligand for the morphine receptor.

Authors:  J Hughes; T Smith; B Morgan; L Fothergill
Journal:  Life Sci       Date:  1975-06-15       Impact factor: 5.037

3.  Stereospecific increase by narcotic antagonists of evoked acetylcholine output in guinea-pig ileum.

Authors:  A A Waterfield; H W Kosterlitz
Journal:  Life Sci       Date:  1975-06-15       Impact factor: 5.037

4.  An analog of enkephalin having prolonged opiate-like effects in vivo.

Authors:  J M Walker; G G Berntson; C A Sandman; D H Coy; A V Schally; A J Kastin
Journal:  Science       Date:  1977-04-01       Impact factor: 47.728

5.  Unexpected reversal effects of naloxone on the guinea pig ileum.

Authors:  J M Van Nueten; A J Janssen; J Fontaine
Journal:  Life Sci       Date:  1976-04-15       Impact factor: 5.037

6.  Endogenous opiate receptor ligand: electrically induced release in the guinea pig ileum.

Authors:  M M Puig; P Gascon; G L Craviso; J M Musacchio
Journal:  Science       Date:  1977-01-28       Impact factor: 47.728

7.  Opioid peptides endorphins in pituitary and brain.

Authors:  A Goldstein
Journal:  Science       Date:  1976-09-17       Impact factor: 47.728

8.  Enkephalins inhibit intestinal motility: mode of action.

Authors:  P Mitznegg; W Domschke; W Sprügel; S Domschke; N Subramanian; E Wünsch; L Moroder; L Demling
Journal:  Acta Hepatogastroenterol (Stuttg)       Date:  1977-04

9.  Inhibition by met-enkephalin of peristaltic activity in the guinea pig ileum, and its reversal by naloxone.

Authors:  J M Van Nueten; J M Van Ree; P M Vanhoutte
Journal:  Eur J Pharmacol       Date:  1977-02-07       Impact factor: 4.432

10.  Morphine-tolerant longitudinal muscle strip from guinea-pig ileum.

Authors:  A Goldstein; R Schulz
Journal:  Br J Pharmacol       Date:  1973-08       Impact factor: 8.739

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  7 in total

Review 1.  Postoperative ileus.

Authors:  E H Livingston; E P Passaro
Journal:  Dig Dis Sci       Date:  1990-01       Impact factor: 3.199

2.  Effect of naloxone on the behaviour of rats exposed to a novel environment.

Authors:  R J Rodgers; R M Deacon
Journal:  Psychopharmacology (Berl)       Date:  1979-09       Impact factor: 4.530

3.  Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat.

Authors:  P Holzer
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

4.  Effect of opiates on gastroduodenal motility following surgical operation.

Authors:  D M Ingram; B N Catchpole
Journal:  Dig Dis Sci       Date:  1981-11       Impact factor: 3.199

5.  A tachykinin antagonist inhibits gastric emptying and gastrointestinal transit in the rat.

Authors:  P Holzer; U Holzer-Petsche; S Leander
Journal:  Br J Pharmacol       Date:  1986-11       Impact factor: 8.739

6.  Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities.

Authors:  Fernando Pereira Beserra; Raquel de Cássia Santos; Larissa Lucena Périco; Vinicius Peixoto Rodrigues; Luiz Ricardo de Almeida Kiguti; Luiz Leonardo Saldanha; André Sampaio Pupo; Lúcia Regina Machado da Rocha; Anne Lígia Dokkedal; Wagner Vilegas; Clélia Akiko Hiruma-Lima
Journal:  Int J Mol Sci       Date:  2016-01-23       Impact factor: 5.923

7.  Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action.

Authors:  Juliana Agostinho Lopes; Vinícius Peixoto Rodrigues; Marcelo Marucci Pereira Tangerina; Lucia Regina Machado da Rocha; Catarine Massucato Nishijima; Vania Vasti Alfieri Nunes; Luiz Fernando Rolim de Almeida; Wagner Vilegas; Adair Roberto Soares Dos Santos; Miriam Sannomiya; Clélia Akiko Hiruma-Lima
Journal:  Biomolecules       Date:  2020-04-11
  7 in total

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