Literature DB >> 216568

Effect of dibutyryl cyclic AMP and analogs on the rate of contractions of myocytes in culture.

K Nath, A P Bollon.   

Abstract

2O, 6N-butyryl, 3', 5'-cyclic monophosphate (dibu cAMP) when added to fetal rat heart cells in culture inhibits myocyte contraction. This inhibition is 100, 84 and 51% complete when the dibu cAMP concentration used is 2, 0.2 and 0.02 mM, respectively. The potency of dibu cAMP derivatives in myocyte contraction inhibition follows the order, dibu cAMP greater than 6N-bu cAMP greater than 2O-bu cAMP = AMP greater than butyrate. The inhibition caused by the first three chemicals is greater than 70%.

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Year:  1978        PMID： 216568     DOI： 10.1007/bf01981418

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  In vitro studies on single beating rat heart cells. II. Intercellular communication.

Authors:  I HARARY; B FARLEY
Journal:  Exp Cell Res       Date:  1963-02       Impact factor: 3.905

2.  Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells.

Authors:  K Nath; J W Shay; A P Bollon
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

3.  An electron microscopy study of the effects on dibutyryl cyclic AMP on Chinese hamster ovary cells.

Authors:  K R Porter; T T Puck; A W Hsie; D Kelley
Journal:  Cell       Date:  1974-07       Impact factor: 41.582

4.  Inotropic and chronotropic effects of dibutyryl cyclic AMP.

Authors:  G I Drummond; S J Hemmings
Journal:  Adv Cyclic Nucleotide Res       Date:  1972

5.  Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone.

Authors:  A W Hsie; T T Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205
  5 in total

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