Sir,I read the recent report on iron status in ESRDpatients with a great interest.[1] Jairam et al. concluded that “our ESRDpatients showed marked inflammatory activation, which was more pronounced in patients who had received IV iron.”[1] I agree that the study on the ESRDpatients is very interesting. I would like to add some more possible clinical explanations to the observation. Recently, Finkelstein et al. studied the correlation between hemoglobin, vitamin C, and peritoneal dialysis.[2] Indeed, the relationship between vitamin C and iron status is confirmed, and vitamin C[3] is also proposed for a possible relationship with hepcidin.[4]
Authors: Fredric O Finkelstein; Peter Juergensen; Suxin Wang; Sally Santacroce; Mark Levine; Peter Kotanko; Nathan W Levin; Garry J Handelman Journal: Perit Dial Int Date: 2010-06-17 Impact factor: 1.756