| Literature DB >> 2165490 |
V M Lipkin1, N V Khramtsov, I A Vasilevskaya, N V Atabekova, K G Muradov, V V Gubanov, T Li, J P Johnston, K J Volpp, M L Applebury.
Abstract
A group of cDNA clones encoding the beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase were isolated for structural analysis. The encoded polypeptide has 853 residues with a calculated molecular mass of 98 kDa. The beta-subunit is 72% identical to the rod cGMP phosphodiesterase alpha-subunit. Like the alpha-subunit and the cone alpha'-subunit, the beta-subunit belongs to the family of phosphodiesterase genes. The beta- and alpha-subunits are more similar to each other than either is to the cone alpha'-subunit, suggesting either that the beta- and alpha-subunits diverged more recently or that their divergence was restrained by the rod functional environment.Entities:
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Year: 1990 PMID： 2165490
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157