BACKGROUND: Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatric osteosarcoma and rhabdomyosarcoma. AIM: To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall. METHODS: Ezrin expression was evaluated by immunohistochemistry on tissue microarrays from a mixed series of 256 soft tissue sarcomas. The expression patterns were correlated to local recurrence and metastasis as well as to established prognostic factors in soft tissue sarcoma. RESULTS: Increased ezrin expression predicted development of metastasis (HR=1.8, 95% CI 1.1 to 2.8; p=0.007) and local recurrence, also after adjustment for surgical margin (HR=2.4, 95% CI 1.4 to 4.3; p=0.02). Correlations to established prognostic factors showed strong associations between ezrin and necrosis (OR=3.9, p<0.0001) and ezrin and growth pattern (OR=3.1, p=0.03). CONCLUSIONS: Ezrin independently predicts development of local recurrences and metastases in soft tissue sarcomas. The possibility of preoperative evaluation makes ezrin a potential marker for identification of high-risk sarcoma patients who would benefit from neoadjuvant therapy.
BACKGROUND:Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatric osteosarcoma and rhabdomyosarcoma. AIM: To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall. METHODS:Ezrin expression was evaluated by immunohistochemistry on tissue microarrays from a mixed series of 256 soft tissue sarcomas. The expression patterns were correlated to local recurrence and metastasis as well as to established prognostic factors in soft tissue sarcoma. RESULTS: Increased ezrin expression predicted development of metastasis (HR=1.8, 95% CI 1.1 to 2.8; p=0.007) and local recurrence, also after adjustment for surgical margin (HR=2.4, 95% CI 1.4 to 4.3; p=0.02). Correlations to established prognostic factors showed strong associations between ezrin and necrosis (OR=3.9, p<0.0001) and ezrin and growth pattern (OR=3.1, p=0.03). CONCLUSIONS:Ezrin independently predicts development of local recurrences and metastases in soft tissue sarcomas. The possibility of preoperative evaluation makes ezrin a potential marker for identification of high-risk sarcomapatients who would benefit from neoadjuvant therapy.
Authors: Ester Antelmi; Rosa A Cardone; Maria R Greco; Rosa Rubino; Francesca Di Sole; Nicola A Martino; Valeria Casavola; Marialuisa Carcangiu; Loredana Moro; Stephan J Reshkin Journal: PLoS One Date: 2013-09-24 Impact factor: 3.240
Authors: Thomas Cash; Hong Yin; Courtney McCracken; Zhi Geng; Steven G DuBois; Bahig M Shehata; Thomas A Olson; Howard M Katzenstein; Cynthia Wetmore Journal: Sarcoma Date: 2017-01-26
Authors: Victoria Hoskin; Alvin Szeto; Abdi Ghaffari; Peter A Greer; Graham P Côté; Bruce E Elliott Journal: Mol Biol Cell Date: 2015-08-05 Impact factor: 4.138