Literature DB >> 21652732

Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.

Ulf Diczfalusy1, Ingemar Björkhem.   

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Year:  2011        PMID： 21652732      PMCID： PMC3137011          DOI： 10.1194/jlr.E017806

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


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  14 in total

1.  Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes.

Authors:  C Furster; K Wikvall
Journal:  Biochim Biophys Acta       Date:  1999-01-29

2.  Structural basis for ligand promiscuity in cytochrome P450 3A4.

Authors:  Marika Ekroos; Tove Sjögren
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-05       Impact factor: 11.205

3.  Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

Authors:  K Bodin; L Bretillon; Y Aden; L Bertilsson; U Broomé; C Einarsson; U Diczfalusy
Journal:  J Biol Chem       Date:  2001-08-20       Impact factor: 5.157

4.  cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.

Authors:  E G Lund; J M Guileyardo; D W Russell
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

5.  Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.

Authors:  Katarina Wide; Hanna Larsson; Leif Bertilsson; Ulf Diczfalusy
Journal:  Br J Clin Pharmacol       Date:  2008-02-12       Impact factor: 4.335

6.  24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver.

Authors:  E Lund; I Björkhem; C Furster; K Wikvall
Journal:  Biochim Biophys Acta       Date:  1993-02-24

7.  cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.

Authors:  E G Lund; T A Kerr; J Sakai; W P Li; D W Russell
Journal:  J Biol Chem       Date:  1998-12-18       Impact factor: 5.157

8.  Transport of side-chain oxidized oxysterols in the human circulation.

Authors:  A Babiker; U Diczfalusy
Journal:  Biochim Biophys Acta       Date:  1998-06-15

9.  25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production.

Authors:  David R Bauman; Andrew D Bitmansour; Jeffrey G McDonald; Bonne M Thompson; Guosheng Liang; David W Russell
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-15       Impact factor: 11.205

10.  CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.

Authors:  Ram P Gupta; You Ai He; Kennerly S Patrick; James R Halpert; Norman H Bell
Journal:  J Clin Endocrinol Metab       Date:  2004-11-16       Impact factor: 5.958
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  6 in total

1.  Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Authors:  Shin-Ichiro Nitta; Mari Hashimoto; Yasuhiro Kazuki; Shoko Takehara; Hiraku Suzuki; Mitsuo Oshimura; Hidetaka Akita; Kan Chiba; Kaoru Kobayashi
Journal:  AAPS J       Date:  2018-04-09       Impact factor: 4.009

Review 2.  Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins.

Authors:  Shijie Mao; Jie Ren; Ying Xu; Jidong Lin; Chuqiao Pan; Yu Meng; Ning Xu
Journal:  Eur J Pharmacol       Date:  2022-05-19       Impact factor: 5.195

3.  PROXIMAL: a method for Prediction of Xenobiotic Metabolism.

Authors:  Mona Yousofshahi; Sara Manteiga; Charmian Wu; Kyongbum Lee; Soha Hassoun
Journal:  BMC Syst Biol       Date:  2015-12-22

Review 4.  Activity of Zearalenone in the Porcine Intestinal Tract.

Authors:  Magdalena Gajęcka; Łukasz Zielonka; Maciej Gajęcki
Journal:  Molecules       Date:  2016-12-24       Impact factor: 4.411

Review 5.  Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival.

Authors:  Qin Cao; Zhongzhong Liu; Yan Xiong; Zibiao Zhong; Qifa Ye
Journal:  Oxid Med Cell Longev       Date:  2020-11-19       Impact factor: 6.543

Review 6.  Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature.

Authors:  Richard Lathe; Alexandra Sapronova; Yuri Kotelevtsev
Journal:  BMC Geriatr       Date:  2014-03-21       Impact factor: 3.921
  6 in total

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