| Literature DB >> 21652207 |
Michael J Stocks1, Lilian Alcaraz, Andrew Bailey, Roger Bonnert, Elaine Cadogan, Jadeen Christie, Stephen Connolly, Anthony Cook, Adrian Fisher, Alice Flaherty, Stephen Hill, Alexander Humphries, Anthony Ingall, Stephen Jordan, Mandy Lawson, Alex Mullen, David Nicholls, Stuart Paine, Garry Pairaudeau, Stephen St-Gallay, Alan Young.
Abstract
The design and synthesis of a new series of high efficacy β(2)-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β(2)-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β(2)-adrenoceptor crystal structure, other biophysical data and modeling studies.Entities:
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Year: 2011 PMID： 21652207 DOI： 10.1016/j.bmcl.2011.04.135
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823