Literature DB >> 2165175

Ca modulates outward current through IK1 channels.

M Mazzanti1, L J DeFelice.   

Abstract

Inward-rectifier channels in cardiac cells (IK1) stabilize the resting membrane potential near the K equilibrium potential. Here we investigate the role of IK1 in the regulation of action potentials and link this to the influx of Ca during beating. Inward Ca current alters the open-channel probability of outward IK1 current. Thus Ca ions depolarize cells not only by carrying an inward current but also by blocking an outward current.

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Year:  1990        PMID： 2165175     DOI： 10.1007/BF01871670

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  15 in total

1.  Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+.

Authors:  H Matsuda; A Saigusa; H Irisawa
Journal:  Nature       Date:  1987 Jan 8-14       Impact factor: 49.962

2.  Outward sodium current in beating heart cells.

Authors:  D P Wellis; L J DeFelice; M Mazzanti
Journal:  Biophys J       Date:  1990-01       Impact factor: 4.033

3.  Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes.

Authors:  R E White; H C Hartzell
Journal:  Science       Date:  1988-02-12       Impact factor: 47.728

4.  Surface charge near the cardiac inward-rectifier channel measured from single-channel conductance.

Authors:  M J Kell; L J DeFelice
Journal:  J Membr Biol       Date:  1988-04       Impact factor: 1.843

5.  Na channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells.

Authors:  M Mazzanti; L J DeFelice
Journal:  Biophys J       Date:  1987-07       Impact factor: 4.033

6.  Intracellular Ca modulates K-inward rectification in cardiac myocytes.

Authors:  M Mazzanti; D DiFrancesco
Journal:  Pflugers Arch       Date:  1989-01       Impact factor: 3.657

7.  K channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells.

Authors:  M Mazzanti; L J DeFelice
Journal:  Biophys J       Date:  1988-12       Impact factor: 4.033

8.  Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart.

Authors:  B Sakmann; G Trube
Journal:  J Physiol       Date:  1984-02       Impact factor: 5.182

9.  Regulation of spontaneous activity and growth of embryonic chick heart cells in tissue culture.

Authors:  R L DeHann
Journal:  Dev Biol       Date:  1967-09       Impact factor: 3.582

10.  Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta-adrenergic agonists and magnesium.

Authors:  I Duchatelle-Gourdon; H C Hartzell; A A Lagrutta
Journal:  J Physiol       Date:  1989-08       Impact factor: 5.182
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  10 in total

1.  Origin of the potassium and voltage dependence of the cardiac inwardly rectifying K-current (IK1).

Authors:  P Pennefather; C Oliva; N Mulrine
Journal:  Biophys J       Date:  1992-02       Impact factor: 4.033

2.  Role of an inwardly rectifying potassium current in rabbit ventricular action potential.

Authors:  Y Shimoni; R B Clark; W R Giles
Journal:  J Physiol       Date:  1992-03       Impact factor: 5.182

3.  The inward rectifier K+ current underlies oscillatory membrane potential behaviour in bovine pigmented ciliary epithelial cells.

Authors:  J W Stelling; T J Jacob
Journal:  J Physiol       Date:  1992-12       Impact factor: 5.182

4.  Dynamics of the inward rectifier K+ current during the action potential of guinea pig ventricular myocytes.

Authors:  J Ibarra; G E Morley; M Delmar
Journal:  Biophys J       Date:  1991-12       Impact factor: 4.033

5.  [Ca²⁺] i-induced augmentation of the inward rectifier potassium current (IK1) in canine and human ventricular myocardium.

Authors:  Norbert Nagy; Károly Acsai; Anita Kormos; Zsuzsanna Sebők; Attila S Farkas; Norbert Jost; Péter P Nánási; Julius Gy Papp; András Varró; András Tóth
Journal:  Pflugers Arch       Date:  2013-06-27       Impact factor: 3.657

Review 6.  Molecular and biophysical view of the Ca channel: a hypothesis regarding oligomeric structure, channel clustering, and macroscopic current.

Authors:  L J DeFelice
Journal:  J Membr Biol       Date:  1993-05       Impact factor: 1.843

7.  Voltage-dependent block by internal Ca2+ ions of inwardly rectifying K+ channels in guinea-pig ventricular cells.

Authors:  H Matsuda; J dos S Cruz
Journal:  J Physiol       Date:  1993-10       Impact factor: 5.182

8.  beta-Adrenergic modulation of the inwardly rectifying potassium channel in isolated human ventricular myocytes. Alteration in channel response to beta-adrenergic stimulation in failing human hearts.

Authors:  S Koumi; C L Backer; C E Arentzen; R Sato
Journal:  J Clin Invest       Date:  1995-12       Impact factor: 14.808

9.  Human ether-à-go-go-related gene K+ channel gating probed with extracellular ca2+. Evidence for two distinct voltage sensors.

Authors:  J P Johnson; F M Mullins; P B Bennett
Journal:  J Gen Physiol       Date:  1999-04       Impact factor: 4.086

10.  Modulation of K+ and Ca2+ channels by histamine H1-receptor stimulation in rabbit coronary artery cells.

Authors:  T Ishikawa; J R Hume; K D Keef
Journal:  J Physiol       Date:  1993-08       Impact factor: 5.182
  10 in total

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