Marine L Andersson1, Linda Björkhem-Bergman, Jonatan D Lindh. 1. Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden. marine.andersson@karolinska.se
Abstract
AIM: The aim of the present study was to investigate a previously proposed interaction between quetiapine and lamotrigine resulting in reduced serum quetiapine concentrations. METHODS: Data on 402 patients subjected to analysis of quetiapine concentration in serum were extracted from a routine therapeutic drug monitoring database. Among these patients, those concomitantly treated with lamotrigine (n= 22) were identified and matched with 22 controls receiving quetiapine while unexposed to lamotrigine. The dose-corrected quetiapine concentrations (C : D ratios) in the two groups were compared in both paired and unpaired analyses. RESULTS: Patients co-treated with lamotrigine had a lower mean C : D ratio (0.71, 95% CI 0.46, 0.97) compared with controls (1.64, 95% CI 1.00, 2.28). Dose-corrected quetiapine concentrations were 58% lower in patients co-medicated with lamotrigine. CONCLUSIONS: This study indicates that lamotrigine exposure is associated with substantially reduced serum concentrations of quetiapine, possibly due to induced glucuronidation. These findings need to be confirmed in experimental studies.
AIM: The aim of the present study was to investigate a previously proposed interaction between quetiapine and lamotrigine resulting in reduced serum quetiapine concentrations. METHODS: Data on 402 patients subjected to analysis of quetiapine concentration in serum were extracted from a routine therapeutic drug monitoring database. Among these patients, those concomitantly treated with lamotrigine (n= 22) were identified and matched with 22 controls receiving quetiapine while unexposed to lamotrigine. The dose-corrected quetiapine concentrations (C : D ratios) in the two groups were compared in both paired and unpaired analyses. RESULTS:Patients co-treated with lamotrigine had a lower mean C : D ratio (0.71, 95% CI 0.46, 0.97) compared with controls (1.64, 95% CI 1.00, 2.28). Dose-corrected quetiapine concentrations were 58% lower in patients co-medicated with lamotrigine. CONCLUSIONS: This study indicates that lamotrigine exposure is associated with substantially reduced serum concentrations of quetiapine, possibly due to induced glucuronidation. These findings need to be confirmed in experimental studies.
Authors: Wolfgang Aichhorn; Ulrike Weiss; Josef Marksteiner; Georg Kemmler; Thomas Walch; Gerald Zernig; Renate Stelzig-Schoeler; Christoph Stuppaeck; Christian Geretsegger Journal: J Psychopharmacol Date: 2005-07 Impact factor: 4.153
Authors: Carlos Figueroa; Martin Brecher; Jennifer E Hamer-Maansson; Helen Winter Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2008-10-09 Impact factor: 5.067
Authors: Haseeb Sattar; Sarmad Sheraz Jadoon; Ni Yang; Shihong Li; Mingzhen Xu; Yong Han; Adil Ramzan; Weiyong Li Journal: Saudi J Med Med Sci Date: 2020-08-20