Literature DB >> 21650188

Mild nonepimerizing N-alkylation of amines by alcohols without transition metals.

Claire Guérin1, Véronique Bellosta, Gérard Guillamot, Janine Cossy.   

Abstract

A one-pot two-step sequence involving an oxidation/imine-iminium formation/reduction allowed the N-alkylation of amines by alcohols without any epimerization when optically active alcohols and amines are involved in the process.

Entities:  

Year:  2011        PMID: 21650188     DOI: 10.1021/ol201351a

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Rapid and efficient access to secondary arylmethylamines.

Authors:  Nicolas Fleury-Brégeot; Jessica Raushel; Deidre L Sandrock; Spencer D Dreher; Gary A Molander
Journal:  Chemistry       Date:  2012-07-05       Impact factor: 5.236

  1 in total

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