Predictors of treatment difficulties and satisfaction with haemophilia therapy in adult patients.

Adherence is a complex and multifaceted behaviour. The study of factors influencing adherence behaviour, including difficulties with treatment and treatment satisfaction (TS), are still needed. This research report describes different questions related to treatment adherence, focusing on perceived barriers and difficulties with treatment, satisfaction with treatment and risk factors that help explain the experience of difficulties and low TS. A cross-sectional study assessing 121 Spanish adult patients (range 17-70) collected information about the characteristics of treatment, perceived barriers to treatment, difficulties and satisfaction with treatment and negative affect. The results show differences in difficulties and satisfaction with treatment depending on haemophilia severity level and describe an association of negative affect with the greater experience of treatment difficulties and lower TS. In conclusion, perceived barriers, level of skills related to self-treatment, haemophilia severity level and affective state are important predictors of treatment difficulties and satisfaction with treatment and these should be taken into account in strategies for improving compliance and maintaining quality of life.