Literature DB >> 2164909

Construction of mammalian cell lines with indicator genes driven by regulated promoters.

J Meinkoth1, A S Alberts, J R Feramisco.   

Abstract

The regulation of gene expression is a central feature of cell growth and differentiation. An important question is how information received at the cell surface is ultimately transmitted to the nucleus and how it causes changes in the pattern of gene expression. To study the molecular basis of this process, we have established cell lines carrying marker genes under the control of known regulatory promoter elements. These cell lines are being used to investigate the effects of activating normal cellular second messenger systems or of microinjecting proteins hypothesized to function in signal transduction, such as oncogene products or subunits of enzymes.

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Year:  1990        PMID： 2164909     DOI： 10.1002/9780470513927.ch4

Source DB:  PubMed          Journal:  Ciba Found Symp        ISSN： 0300-5208


  11 in total

1.  Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.

Authors:  J L Meinkoth; Y Ji; S S Taylor; J R Feramisco
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Creation of an In vivo cytosensor using engineered mesangial cells. Automatic sensing of glomerular inflammation controls transgene activity.

Authors:  M Kitamura; H Kawachi
Journal:  J Clin Invest       Date:  1997-09-15       Impact factor: 14.808

3.  Differential regulation of cellular activities by GTPase-activating protein and NF1.

Authors:  N al-Alawi; G Xu; R White; R Clark; F McCormick; J R Feramisco
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

4.  Regulation of c-fos and c-jun protooncogene expression by the Ca(2+)-ATPase inhibitor thapsigargin.

Authors:  A Schönthal; J Sugarman; J H Brown; M R Hanley; J R Feramisco
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

5.  cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment.

Authors:  J Thome; N Sakai; K Shin; C Steffen; Y J Zhang; S Impey; D Storm; R S Duman
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

6.  A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

Authors:  J A Frost; T D Geppert; M H Cobb; J R Feramisco
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

7.  Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.

Authors:  A S Alberts; T Deng; A Lin; J L Meinkoth; A Schönthal; M C Mumby; M Karin; J R Feramisco
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

8.  Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism.

Authors:  D Parker; K Ferreri; T Nakajima; V J LaMorte; R Evans; S C Koerber; C Hoeger; M R Montminy
Journal:  Mol Cell Biol       Date:  1996-02       Impact factor: 4.272

9.  Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.

Authors:  A S Alberts; M Montminy; S Shenolikar; J R Feramisco
Journal:  Mol Cell Biol       Date:  1994-07       Impact factor: 4.272

10.  Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.

Authors:  Daniel M Fass; Surya A Reis; Balaram Ghosh; Krista M Hennig; Nadine F Joseph; Wen-Ning Zhao; Thomas J F Nieland; Ji-Song Guan; Chelsea E Groves Kuhnle; Weiping Tang; Douglas D Barker; Ralph Mazitschek; Stuart L Schreiber; Li-Huei Tsai; Stephen J Haggarty
Journal:  Neuropharmacology       Date:  2012-07-04       Impact factor: 5.250
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