OBJECTIVES: To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships. METHODS: Subjects were 441 adolescents, 14-18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays. RESULTS: Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p = 0.0017) and black girls had the highest leptin (p = 0.0164). Percent BF and leptin were positively correlated (p = 0.0164). The %BF-leptin relationship was stronger in boys than girls (p < 0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p = 0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender. CONCLUSION: Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.
OBJECTIVES: To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships. METHODS: Subjects were 441 adolescents, 14-18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays. RESULTS: Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p = 0.0017) and black girls had the highest leptin (p = 0.0164). Percent BF and leptin were positively correlated (p = 0.0164). The %BF-leptin relationship was stronger in boys than girls (p < 0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p = 0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender. CONCLUSION: Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.
Authors: S Y Kimm; B A Barton; E Obarzanek; R P McMahon; Z I Sabry; M A Waclawiw; G B Schreiber; J A Morrison; S Similo; S R Daniels Journal: Pediatrics Date: 2001-03 Impact factor: 7.124
Authors: Cynthia L Ogden; Margaret D Carroll; Lester R Curtin; Margaret A McDowell; Carolyn J Tabak; Katherine M Flegal Journal: JAMA Date: 2006-04-05 Impact factor: 56.272
Authors: W F Blum; P Englaro; S Hanitsch; A Juul; N T Hertel; J Müller; N E Skakkebaek; M L Heiman; M Birkett; A M Attanasio; W Kiess; W Rascher Journal: J Clin Endocrinol Metab Date: 1997-09 Impact factor: 5.958
Authors: Yong Qi; Nobuhiko Takahashi; Stanley M Hileman; Hiralben R Patel; Anders H Berg; Utpal B Pajvani; Philipp E Scherer; Rexford S Ahima Journal: Nat Med Date: 2004-04-11 Impact factor: 53.440