Literature DB >> 2164815

Complexation and medium effects on the conformation of cyclosporin A studied by NMR spectroscopy and molecular dynamics calculations.

H Kessler1, M Gehrke, J Lautz, M Köck, D Seebach, A Thaler.   

Abstract

The conformation of cyclosporin A was investigated in different environments. Whereas there was no distinct difference between the structure of CSA in CDCl3 and THF, the addition of LiCl caused a conformational change. Also, using polar solvents (DMSO, water) induced conformational changes in the backbone as well as the side chains.

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Year:  1990        PMID： 2164815     DOI： 10.1016/0006-2952(90)90192-n

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  4 in total

1.  Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.

Authors:  Christopher L Ahlbach; Katrina W Lexa; Andrew T Bockus; Valerie Chen; Phillip Crews; Matthew P Jacobson; R Scott Lokey
Journal:  Future Med Chem       Date:  2015-06-12       Impact factor: 3.808

2.  NMR structural characterization of oligo-N-substituted glycine lead compounds from a combinatorial library.

Authors:  E K Bradley; J M Kerr; L S Richter; G M Figliozzi; D A Goff; R N Zuckermann; D C Spellmeyer; J M Blaney
Journal:  Mol Divers       Date:  1997       Impact factor: 2.943

3.  Solubilization of cyclosporin A.

Authors:  Y Ran; L Zhao; Q Xu; S H Yalkowsky
Journal:  AAPS PharmSciTech       Date:  2001-01-18       Impact factor: 3.246

4.  Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity.

Authors:  Akihiro Furukawa; Joshua Schwochert; Cameron R Pye; Daigo Asano; Quinn D Edmondson; Alexandra C Turmon; Victoria G Klein; Satoshi Ono; Okimasa Okada; R Scott Lokey
Journal:  Angew Chem Int Ed Engl       Date:  2020-09-17       Impact factor: 15.336
  4 in total

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