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Literature DB >> 2164647

Changes in cerebral inositol-1-phosphate concentrations in LiCl-treated rats: regional and strain differences.

K M Savolainen¹, M R Hirvonen, J Tarhanen, S R Nelson, F E Samson, T L Pazdernik.

Abstract

LiCl-induced (5 mEq/kg) regional differences in the cerebral phosphoinositide (PI) cycle were studied by measuring inositol-1-phosphate (Ins-1-P), an intermediate in the PI cycle, in male Sprague Dawley and Han/Wistar rats by gas chromatography/mass spectrometry. Control Ins-1-P levels were higher frontally than caudally in both rat strains. LiCl increased Ins-1-P levels 1.8 to 7.4 fold in different regions of brain of Sprague Dawley rats but only 1.2 to 1.8 fold in Han/Wistar rats. This strain difference offers a way to compare the effects of lithium on PI metabolism versus receptor-G protein-phospholipase C coupling mechanisms.

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Year: 1990 PMID： 2164647 DOI： 10.1007/BF00966214

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

19 in total

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Journal: J Biol Chem Date: 1980-11-25 Impact factor: 5.157

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Journal: Neurochem Res Date: 1989-02 Impact factor: 3.996

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Journal: Nature Date: 1984 Nov 22-28 Impact factor: 49.962

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Authors: M R Hirvonen; H Lihtamo; K Savolainen
Journal: Neurochem Res Date: 1988-10 Impact factor: 3.996

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Journal: J Neurochem Date: 1985-10 Impact factor: 5.372

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Authors: M R Hirvonen; H Komulainen; K Savolainen
Journal: Neurochem Res Date: 1993-05 Impact factor: 3.996

3 in total