AIMS: To explore associations between IRS-1 rs1801278 G>A polymorphism and metabolic syndrome (MS). METHODS: rs1801278 G>A was genotyped in 610 healthy Argentinian men. RESULTS: GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006). CONCLUSIONS: rs1801278 GA carriers had lower risk of MS, especially among smokers.
AIMS: To explore associations between IRS-1rs1801278 G>A polymorphism and metabolic syndrome (MS). METHODS:rs1801278 G>A was genotyped in 610 healthy Argentinian men. RESULTS: GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006). CONCLUSIONS:rs1801278 GA carriers had lower risk of MS, especially among smokers.
Authors: Ju-Sheng Zheng; Donna K Arnett; Laurence D Parnell; Caren E Smith; Duo Li; Ingrid B Borecki; Katherine L Tucker; José M Ordovás; Chao-Qiang Lai Journal: Diabetes Care Date: 2013-04-17 Impact factor: 19.112