| Literature DB >> 21645648 |
S Bonneux1, E Fransen, E Van Eyken, L Van Laer, J Huyghe, P Van de Heyning, A Voets, M Gerards, A P M Stassen, A T M Hendrickx, H J M Smeets, G Van Camp.
Abstract
Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.Entities:
Mesh：
Year: 2011 PMID： 21645648 DOI： 10.1016/j.mito.2011.05.008
Source DB: PubMed Journal: Mitochondrion ISSN： 1567-7249 Impact factor: 4.160