Literature DB >> 216451

Cyclic adenosine 3', 5'-monophosphate and the mechanism of action of three common anti-inflammatory drugs.

D A Deporter, C J Dunn, D A Willoughby.   

Abstract

1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3', 5'-monophosphate (cyclic AMP) concentration in leucocytes during a crystal-induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti-inflammatory drug.

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Year:  1979        PMID： 216451      PMCID： PMC1668606          DOI： 10.1111/j.1476-5381.1979.tb07814.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  17 in total

1.  The effects of indomethacin and prostaglandin E1 on cyclic AMP levels in frog skin.

Authors:  W J Hall; M G O'Regan
Journal:  J Physiol       Date:  1975-05       Impact factor: 5.182

2.  The last conversation with Dr. Earl W. Sutherland, Jr: the feedback regulation of cyclic nucleotides.

Authors:  R J Ho; T Russell; T Asakawa
Journal:  Metabolism       Date:  1975-03       Impact factor: 8.694

3.  Cartilage cyclic nucleotide phosphodiesterase: inhibition by anti-inflammatory agents.

Authors:  D S Newcombe; N M Thanassi; C P Ciosek
Journal:  Life Sci       Date:  1974-02-01       Impact factor: 5.037

4.  Inhibition of 3',5'-cyclic AMP phosphodiesterase with anti-inflammatory agents.

Authors:  V Stefanovich
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1974-03

5.  Endogenous prostaglandins and osmotic water flow in the toad bladder.

Authors:  A G Flores; G W Sharp
Journal:  Am J Physiol       Date:  1972-12

6.  Indomethacin potentiates PGE1 stimulated cyclic AMP accumulation in human synoviocytes.

Authors:  C P Ciosek; R W Ortel; N M Thanassi; D S Newcombe
Journal:  Nature       Date:  1974-09-13       Impact factor: 49.962

7.  Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. II. Influence of cellular levels of cyclic AMP.

Authors:  R P Orange; M A Kaliner; P J Laraia; K F Austen
Journal:  Fed Proc       Date:  1971 Nov-Dec

8.  An effect of dexamethasone on adenosine 3',5'-monophosphate content and adenosine 3',5'-monophosphate phosphodiesterase activity of cultured hepatoma cells.

Authors:  V Manganiello; M Vaughan
Journal:  J Clin Invest       Date:  1972-10       Impact factor: 14.808

9.  Effects of colchicine on cyclic AMP levels in human leukocytes.

Authors:  S A Rudolph; P Greengard; S E Malawista
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

10.  The relation of cyclic AMP levels to phagocytosis and enzyme release in acute inflammation in vivo.

Authors:  D A Deporter; P A Dieppe; M Glatt; D A Willoughby
Journal:  J Pathol       Date:  1977-03       Impact factor: 7.996
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  4 in total

1.  Professor Derek Albert Willoughby (1930-2004).

Authors:  K D Rainsford
Journal:  Inflammopharmacology       Date:  2005       Impact factor: 4.473

2.  Antrafenine: anti-inflammatory activity with respect to oedema and leucocyte infiltration in the rat.

Authors:  C J Dunn; M Prouteau; M Delahaye; T Purcell; D Branceni
Journal:  Agents Actions       Date:  1984-02

3.  Effect of purified protein derivative and sonicates of Mycobacterium leprae and Mycobacterium bovis BCG on thromboplastin response in human monocytes in vitro.

Authors:  T Lyberg; O Closs; H Prydz
Journal:  Infect Immun       Date:  1982-12       Impact factor: 3.441

4.  Phorbol esters induce synthesis of thromboplastin activity in human monocytes.

Authors:  T Lyberg; H Prydz
Journal:  Biochem J       Date:  1981-03-15       Impact factor: 3.857
  4 in total

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