BACKGROUND: Asthma exacerbations are one of the most common causes of hospitalization in children and account for approximately 10,000 intensive care unit (ICU) admissions per year in the United States. Despite the prevalence of this disease in children, the factors associated with the development of these severe exacerbations are largely unknown. METHODS: A retrospective case-control study was conducted involving all eligible children admitted to the hospital with asthma for a 1-year period. Potential associated factors and outcomes of children admitted to the ICU with a severe exacerbation (cases) were compared to those of children with acute asthma admitted to the ward (controls). RESULTS: A total of 188 children were hospitalized with asthma during the study period, 57 (30%) of whom required admission to the ICU. There were no differences in age, gender, or race between cases and controls. Children admitted to the ICU were significantly more likely to have an allergy or irritant-triggered exacerbation than children admitted to the ward (OR 3.9; 95% CI 1.9-8.2; p = .0003). Additionally, children in the ICU had a significantly shorter duration of illness before being admitted to the hospital compared to those admitted to the ward (1.7 ± 2.3 vs. 3.4 ± 4.8 days; p = .002). CONCLUSIONS: In this retrospective review, severe asthma exacerbations in children are associated with a more rapid onset of symptoms and are more likely to be associated with allergens or irritants, supporting the importance of atopy in this population.
BACKGROUND: Asthma exacerbations are one of the most common causes of hospitalization in children and account for approximately 10,000 intensive care unit (ICU) admissions per year in the United States. Despite the prevalence of this disease in children, the factors associated with the development of these severe exacerbations are largely unknown. METHODS: A retrospective case-control study was conducted involving all eligible children admitted to the hospital with asthma for a 1-year period. Potential associated factors and outcomes of children admitted to the ICU with a severe exacerbation (cases) were compared to those of children with acute asthma admitted to the ward (controls). RESULTS: A total of 188 children were hospitalized with asthma during the study period, 57 (30%) of whom required admission to the ICU. There were no differences in age, gender, or race between cases and controls. Children admitted to the ICU were significantly more likely to have an allergy or irritant-triggered exacerbation than children admitted to the ward (OR 3.9; 95% CI 1.9-8.2; p = .0003). Additionally, children in the ICU had a significantly shorter duration of illness before being admitted to the hospital compared to those admitted to the ward (1.7 ± 2.3 vs. 3.4 ± 4.8 days; p = .002). CONCLUSIONS: In this retrospective review, severe asthma exacerbations in children are associated with a more rapid onset of symptoms and are more likely to be associated with allergens or irritants, supporting the importance of atopy in this population.
Authors: Amelia Licari; Ilaria Brambilla; Alessia Marseglia; Maria De Filippo; Valeria Paganelli; Gian L Marseglia Journal: Front Pediatr Date: 2018-06-19 Impact factor: 3.418
Authors: Sofia Cividini; Ian Sinha; Sarah Donegan; Michelle Maden; Giovanna Culeddu; Katie Rose; Olive Fulton; Dyfrig A Hughes; Stephen Turner; Catrin Tudur Smith Journal: BMJ Open Date: 2021-02-05 Impact factor: 2.692
Authors: Anne M Fitzpatrick; Leonard B Bacharier; Daniel J Jackson; Stanley J Szefler; Avraham Beigelman; Michael Cabana; Ronina Covar; Theresa Guilbert; Fernando Holguin; Robert F Lemanske; Fernando D Martinez; Wayne Morgan; Wanda Phipatanakul; Jacqueline A Pongracic; Hengameh H Raissy; Robert S Zeiger; David T Mauger Journal: J Allergy Clin Immunol Pract Date: 2020-03-07
Authors: Ayman A Al-Eyadhy; Mohamad-Hani Temsah; Ali A N Alhaboob; Abdulmalik K Aldubayan; Nasser A Almousa; Abdulrahman M Alsharidah; Mohammed I Alangari; Abdulrahman M Alshaya Journal: Ann Thorac Med Date: 2015 Oct-Dec Impact factor: 2.219
Authors: Shelley A Boeschoten; Corinne M P Buysse; Peter J F M Merkus; Jacob M C van Wijngaarden; Sabien G J Heisterkamp; Johan C de Jongste; Joost van Rosmalen; Suzan C M Cochius-den Otter; Annemie L M Boehmer; Matthijs de Hoog Journal: Pediatr Pulmonol Date: 2018-04-10