Column design for electrochemically modulated liquid chromatography.

A new column design for electrochemically modulated liquid chromatography (EMLC) is presented. The principal attribute of the new design is the enhancement of the control over the potential applied to the stationary phase by the reduction of the background current and solution resistance. The enhancement is demonstrated through a series of comparisons of the electrochemical performance of the new and the earlier column designs. This enhancement, as shown using mixtures of aromatic sulfonates, translates to an improvement in the capability of EMLC as a separation technique.