Literature DB >> 21643561

Unexpected phosphodiesterase activity at low pH of a dinuclear copper-β-cyclodextrin complex.

Meng Zhao1, Han-Lu Wang, Li Zhang, Cunyuan Zhao, Liang-Nian Ji, Zong-Wan Mao.   

Abstract

A surprisingly low pK(a) (4.3) for a Cu(II) bridging water was found in the presented complex, Cu(2)L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn(2)L at typical lysosomal pH (~5.0).

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Year:  2011        PMID: 21643561     DOI: 10.1039/c1cc12466h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  Remarkable reactivity of alkoxide/acetato-bridged binuclear copper(II) complex as artificial carboxylesterase.

Authors:  Bin Xu; Weidong Jiang; Xiaoqiang Liu; Fuan Liu; Zheng Xiang
Journal:  J Biol Inorg Chem       Date:  2017-03-31       Impact factor: 3.358

2.  Enantioselective Hydrolysis of Amino Acid Esters Promoted by Bis(β-cyclodextrin) Copper Complexes.

Authors:  Shan-Shan Xue; Meng Zhao; Zhuo-Feng Ke; Bei-Chen Cheng; Hua Su; Qian Cao; Zhen-Kun Cao; Jun Wang; Liang-Nian Ji; Zong-Wan Mao
Journal:  Sci Rep       Date:  2016-02-26       Impact factor: 4.379

  2 in total

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