| Literature DB >> 21642398 |
Sachin Baidya1, Jeffrey W Cary, W Scott Grayburn, A M Calvo.
Abstract
Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin production. Supplementation with a nitric oxide-releasing compound promoted cleistothecial formation and increased nsdD and steA expression, indicating that nitric oxide induces sexual development. This is the first study on the effect of nitric oxide on morphogenesis and secondary metabolism in fungi.Entities:
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Year: 2011 PMID: 21642398 PMCID: PMC3147476 DOI: 10.1128/AEM.00638-11
Source DB: PubMed Journal: Appl Environ Microbiol ISSN: 0099-2240 Impact factor: 4.792