Literature DB >> 21642057

The underutilization of intrathecal baclofen in poststroke spasticity.

Eric M Dvorak1, Nicholas C Ketchum, John R McGuire.   

Abstract

Stroke is one of the leading causes of adult disability in the United States, with a reported prevalence of 6.4 million people. Spasticity is one of the clinical features of the upper motor neuron syndrome seen after a stroke. The prevalence of spasticity after a stroke ranges from 17% to 42.6%, and an average of two-thirds of people with spasticity have upper and lower extremity involvement. Oral medications and botulinum neurotoxin injections are current treatments for problematic spasticity. However, these treatments are often limited by side effects or dose ceilings. Intrathecal baclofen (ITB) is a proven method for the management of disabling spasticity from multiple etiologies. Studies have demonstrated improved mobility, activities of daily living, and quality of life in spastic poststroke patients. Despite the benefits of ITB, fewer than 1% of stroke patients with severe disabling spasticity are being treated with ITB. This article will review the prevalence of severe poststroke spasticity and the rate of ITB use and will discuss reasons for its limited use in stroke survivors.

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Year:  2011        PMID: 21642057     DOI: 10.1310/tsr1803-195

Source DB:  PubMed          Journal:  Top Stroke Rehabil        ISSN: 1074-9357            Impact factor:   2.119


  4 in total

Review 1.  Safety and efficacy of incobotulinumtoxinA as a potential treatment for poststroke spasticity.

Authors:  Andrea Santamato
Journal:  Neuropsychiatr Dis Treat       Date:  2016-01-27       Impact factor: 2.570

2.  Intrathecal baclofen therapy versus conventional medical management for severe poststroke spasticity: results from a multicentre, randomised, controlled, open-label trial (SISTERS).

Authors:  Michael Creamer; Geoffrey Cloud; Peter Kossmehl; Michael Yochelson; Gerard E Francisco; Anthony B Ward; Jörg Wissel; Mauro Zampolini; Abdallah Abouihia; Nathalie Berthuy; Alessandra Calabrese; Meghann Loven; Leopold Saltuari
Journal:  J Neurol Neurosurg Psychiatry       Date:  2018-01-11       Impact factor: 10.154

3.  Cerebellar Intermittent Theta-Burst Stimulation Reduces Upper Limb Spasticity After Subacute Stroke: A Randomized Controlled Trial.

Authors:  Yi Chen; Qing-Chuan Wei; Ming-Zhi Zhang; Yun-Juan Xie; Ling-Yi Liao; Hui-Xin Tan; Qi-Fan Guo; Qiang Gao
Journal:  Front Neural Circuits       Date:  2021-10-27       Impact factor: 3.492

4.  Effect of Intrathecal Baclofen on Pain and Quality of Life in Poststroke Spasticity.

Authors:  Michael Creamer; Geoffrey Cloud; Peter Kossmehl; Michael Yochelson; Gerard E Francisco; Anthony B Ward; Jörg Wissel; Mauro Zampolini; Abdallah Abouihia; Alessandra Calabrese; Leopold Saltuari
Journal:  Stroke       Date:  2018-09       Impact factor: 7.914

  4 in total

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