Literature DB >> 21641593

The D-chiro-inositol paradox in the ovary.

Gianfranco Carlomagno1, Vittorio Unfer, Scott Roseff.   

Abstract

The D-chiro-inositol-to-myo-inositol ratio is regulated by an insulin-dependent epimerase. Enzyme activity varies among tissues, likely owing to the specific needs of the two different molecules. We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in turn is responsible for the poor oocyte quality.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21641593     DOI： 10.1016/j.fertnstert.2011.05.027

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  29 in total

Review 1.  The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Authors:  Mark P Thomas; Stephen J Mills; Barry V L Potter
Journal:  Angew Chem Int Ed Engl       Date:  2015-12-22       Impact factor: 15.336

2.  Inositol for subfertile women with polycystic ovary syndrome.

Authors:  Marian G Showell; Rebecca Mackenzie-Proctor; Vanessa Jordan; Ruth Hodgson; Cindy Farquhar
Journal:  Cochrane Database Syst Rev       Date:  2018-12-20

3.  Myo-Inositol in the Treatment of Teenagers Affected by PCOS.

Authors:  Lali Pkhaladze; Ludmila Barbakadze; Nana Kvashilava
Journal:  Int J Endocrinol       Date:  2016-08-18       Impact factor: 3.257

4.  Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality.

Authors:  Bernd Lesoine; Pedro-Antonio Regidor
Journal:  Int J Endocrinol       Date:  2016-08-22       Impact factor: 3.257

Review 5.  Inositol Treatment and ART Outcomes in Women with PCOS.

Authors:  Deepika Garg; Reshef Tal
Journal:  Int J Endocrinol       Date:  2016-10-04       Impact factor: 3.257

Review 6.  Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials.

Authors:  Vittorio Unfer; John E Nestler; Zdravko A Kamenov; Nikos Prapas; Fabio Facchinetti
Journal:  Int J Endocrinol       Date:  2016-10-23       Impact factor: 3.257

Review 7.  Inositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies.

Authors:  Elisa Lepore; Rosa Lauretta; Marta Bianchini; Marilda Mormando; Cherubino Di Lorenzo; Vittorio Unfer
Journal:  Int J Mol Sci       Date:  2021-06-24       Impact factor: 5.923

8.  CONCERN: Does ovary need D-chiro-inositol?

Authors:  Rosalbino Isabella; Emanuela Raffone
Journal:  J Ovarian Res       Date:  2012-05-15       Impact factor: 4.234

Review 9.  Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols.

Authors:  Antonio Simone Laganà; Paola Rossetti; Massimo Buscema; Sandro La Vignera; Rosita Angela Condorelli; Giuseppe Gullo; Roberta Granese; Onofrio Triolo
Journal:  Int J Endocrinol       Date:  2016-08-04       Impact factor: 3.257

Review 10.  How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin.

Authors:  Salvatore Giovanni Vitale; Paola Rossetti; Francesco Corrado; Agnese Maria Chiara Rapisarda; Sandro La Vignera; Rosita Angela Condorelli; Gaetano Valenti; Fabrizio Sapia; Antonio Simone Laganà; Massimo Buscema
Journal:  Int J Endocrinol       Date:  2016-08-29       Impact factor: 3.257
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